Reproductive System, Female

Ovary - Necrosis

    Narrative
    Ovary - Necrosis in a female F344/N rat from a chronic study. The necrotic ovarian tissue is sharply demarcated from the adjacent ovary.
    Ovary - Necrosis in a female F344/N rat from a chronic study (higher magnification of Figure 1). The necrotic ovarian tissue is demarcated from the adjacent ovarian stroma.
    Ovary - Necrosis in a female F344/N rat from a chronic study (higher magnification of Figure 2). There are pyknotic cells and cellular debris and adjacent mononuclear cells and neutrophils.

    Authors

    Gabrielle Willson, BVMS, Dip RC Path, FRC Path, MRCVS
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Karen Y. Cimon, DVM, MS
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Reviewers

    Karen S. Regan, DVM, DABT, DACVP
    Pathologist
    Regan Path/Tox Services, Inc.
    Ashland, OH  

    Darlene Dixon, DVM, PhD, DACVP, Fellow, IATP
    Group Leader, Molecular Pathogenesis Group
    National Toxicology Program Laboratory
    National Toxicology Program
    National Institute of Environmental Health Sciences, Research Triangle Park, NC