Reproductive System, Female

Oviduct - Atrophy

    Narrative
    Oviduct - Atrophy in a female B6C3F1/N mouse from a chronic study. The fimbria in the infundibulum are small and collapsed (arrow) and the folds of epithelium in the isthmus are blunted (asterisk).
    Oviduct - Normal in a female B6C3F1/N mouse from a subchronic study. The fimbria in the infundibulum (arrow) and epithelial folds in the isthmus (asterisk) are well formed (compare to Figure 1).
    Oviduct - Atrophy in a female B6C3F1/N mouse from a chronic study (higher magnification of Figure 1). The cells in the infundibular fimbria (arrow) are vacuolated.
    Oviduct - Normal in a female B6C3F1/N mouse from a subchronic study. The cells of the infubdibular fimbria lack vacuoles (compare to Figure 3).

    Authors

    Gabrielle Willson, BVMS, Dip RC Path, FRC Path, MRCVS
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Karen Y. Cimon, DVM, MS
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Reviewers

    Karen S. Regan, DVM, DABT, DACVP
    Pathologist
    Regan Path/Tox Services, Inc.
    Ashland, OH  

    Darlene Dixon, DVM, PhD, DACVP, Fellow, IATP
    Group Leader, Molecular Pathogenesis Group
    National Toxicology Program Laboratory
    National Toxicology Program
    National Institute of Environmental Health Sciences, Research Triangle Park, NC