Reproductive System, Female

Uterus - Hyperplasia, Atypical

    Narrative
    Uterus, Endometrium - Hyperplasia, Atypical in a female Wistar Han rat from a chronic study. The glandular epithelium projects into the glandular lumen (arrow), forming multiple thickened infoldings and projections.
    Uterus, Endometrium - Hyperplasia, Atypical in a female Wistar Han rat from a chronic study (higher magnification of Figure 1). There are multiple infoldings and projections of the endometrium into the uterine lumen.
    Uterus, Endometrium - Hyperplasia, Atypical in a female Wistar Han rat from a chronic study. The epithelium lining the uterine lumen projects into the lumen in irregular papillary fronds.
    Uterus, Endometrium - Hyperplasia, Atypical in a female Wistar Han rat from a chronic study (higher magnification of Figure 3). The epithelial cells are irregularly arranged and exhibit cellular pleomorphism.
    Uterus - Hyperplasia, Atypical in a female Harlan Sprague-Dawley rat from a chronic study. There is atypical hyperplasia of both surface and glandular epithelium.

    Authors

    Gabrielle Willson, BVMS, Dip RC Path, FRC Path, MRCVS
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Karen Y. Cimon, DVM, MS
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Reviewers

    Karen S. Regan, DVM, DABT, DACVP
    Pathologist
    Regan Path/Tox Services, Inc.
    Ashland, OH  

    Darlene Dixon, DVM, PhD, DACVP, Fellow, IATP
    Group Leader, Molecular Pathogenesis Group
    National Toxicology Program Laboratory
    National Toxicology Program
    National Institute of Environmental Health Sciences, Research Triangle Park, NC