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Uterus - Hyperplasia, Stromal

Image of hyperplasia, stromal in the uterus from a female F344/N rat in a chronic study
Uterus - Hyperplasia, Stromal in a female F344/N rat from a chronic study. There is stromal hyperplasia of the endometrium with concomitant thickening of uterine wall.
Figure 1 of 2
Image of hyperplasia, stromal in the uterus from a female F344/N rat in a chronic study
Uterus - Hyperplasia, Stromal in a female F344/N rat from a chronic study. There is an increase in the stromal component of the endometrium.
Figure 2 of 2
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comment:

Stromal hyperplasia is characterized as a general increase in stromal tissue, smooth muscle, and connective tissue resulting in an increase in myometrial thickness ( Figure 1image opens in a pop-up window and Figure 2image opens in a pop-up window ). This may result in gross enlargement of the uterus.

recommendation:

Uterus - Hyperplasia, Stromal should be diagnosed and assigned a grade whenever present.

references:

National Toxicology Program. 1999. NTP TR-485. Toxicology and Carcinogenesis Studies of Oxymetholone (CAS No. 434-07-01) in F344/N Rats and Toxicology Studies of Oxymetholone in B6C3F1 Mice (Gavage Studies). NTP, Research Triangle Park, NC.
Abstract: http://ntp.niehs.nih.gov/go/9771

National Toxicology Program. 2014. NTP TR-584. Toxicology Studies of Indole-3-Carbinol (CAS No. 700-06-1) in F344/N Rats and B6C3F1 Mice and Toxicology and Carcinogenesis Studies of Indole-3-Carbinol in Harlan Sprague Dawley Rats and B6C3F1/N Mice (Gavage Studies). NTP, Research Triangle Park, NC.
Abstract: http://ntp.niehs.nih.gov/go/41482