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Uterus - Thrombus

Image of thrombus in the uterus from a female B6C3F1 mouse in a chronic study
Uterus - Thrombus in a female B6C3F1/N mouse from a chronic study. A large thrombus is evident in the myometrium.
Figure 1 of 2
Image of thrombus in the uterus from a female B6C3F1 mouse in a chronic study
Uterus - Thrombus in a female B6C3F1/N mouse from a chronic study (higher magnification of Figure 1). Flattened endothelial cells are evident lining the vascular spaces.
Figure 2 of 2
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comment:

Large or small thrombi may occlude uterine blood vessels in mice ( Figure 1image opens in a pop-up window and Figure 2image opens in a pop-up window ). A distinct endothelial lining may not be observed due to necrosis or obscuring by detritus. This may be associated with prominence and dilation of the surrounding blood vessels (angiectasis). Thrombi must be differentiated from hemangioma and hemangiosarcoma. Angiectasis is characterized by blood vessels lined by a simple nonhypertrophic endothelial lining and is frequently seen with thrombosis. Hemangioma and hemangiosarcoma have plump lining endothelial cells. The endothelial cells of hemangiosarcoma exhibit anaplasia and an increased rate of mitoses.

recommendation:

Uterus - Thrombosis should be diagnosed but need not be graded. Thrombi that are secondary to another process (a neoplasm) should not be diagnosed. Necrosis that is caused by a thrombus should be diagnosed and graded separately.

references:

Davis BJ, Dixon D, Herbert RA. 1999. Ovary, oviduct, uterus, cervix and vagina. In: Pathology of the Mouse: Reference and Atlas (Maronpot RR, Boorman GA, Gaul BW, eds). Cache River Press, Vienna, IL, 409-444.

Maekawa A, Maita K. 1996. Changes in the uterus and vagina. In: Pathobiology of the Aging Mouse (Mohr U, Dungworth DL, Capen CC, Carlton WW, Sundberg JP, Ward JM, eds). ILSI Press, Washington, DC, 469-480.

National Toxicology Program. 1993. NTP TR-428. Toxicology and Carcinogenesis Studies of Manganese (II) Sulfate Monohydrate (CAS No. 10034-96-5) in F344/N Rats and B6C3F1 Mice (Feed Studies). NTP, Research Triangle Park, NC.
Abstract: http://ntp.niehs.nih.gov/go/6000

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.