Reproductive System, Female
Vagina - Ulcer
Narrative
An ulcer of the vagina is a focal loss of the epithelium with a breach of the underlying basement membrane (Figure 1 and Figure 2). There is typically an associated inflammatory cell reaction. It is most commonly seen as a consequence of local, intravaginal administration of materials such as pessaries and xenobiotics.
Vagina - Ulcer should be diagnosed and graded. The associated inflammation should not be diagnosed separately unless warranted by severity but should be described in the pathology narrative.
Dixon D, Alison R, Bach U, Colman K, Foley GL, Harleman JH, Hawarth R, Herbert R, Heuser A, Long G, Mirsky M, Regan K, Van Esch E, Westwood FR, Vidal J, Yoshida M. 2014. Nonproliferative and proliferative lesions of the rat and mouse female reproductive system (INHAND). J Toxicol Pathol 27(suppl):1S-107S.
Full Text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253081/Greaves P. 2012. Female genital tract. In: Histopathology of Preclinical Toxicity Studies: Interpretation and Relevance in Drug Safety Evaluations, 4th ed. Elsevier, Amsterdam, 667-724.
Vagina - Ulcer in a female Harlan Sprague-Dawley rat from a chronic study. There is a focal area of ulceration of the vagina epithelium.
All Images
Vagina - Ulcer in a female Harlan Sprague-Dawley rat from a chronic study. There is a focal area of ulceration of the vagina epithelium.
Vagina - Ulcer in a female Harlan Sprague-Dawley rat from a chronic study (higher magnification of Figure 1). There is loss of epithelium in a focal area of the vagina.