Hematopoietic System

Bone Marrow - Hypocellularity

    Narrative
    Bone marrow in a control female F344/N rat from a subchronic study.
    Bone marrow in a treated female F344/N rat from a subchronic study. Compared with concurrent control (Figure 1), there is mild hypocellularity.
    Bone marrow in a control female F344/N rat from a subchronic study (higher magnification of Figure 1).
    Bone marrow in a treated female F344/N rat from a subchronic study (higher magnification of Figure 2). Compared with concurrent control (Figure 3), there is mild bone marrow hypocellularity.
    Severely hypocellular bone marrow in a male B6C3F1 mouse from a subchronic study. The marrow space is largely devoid of hematopoietic cells and consists primarily of adipose tissue and vascular sinuses due to treatment-induced aplastic anemia.
    Severely hypocellular bone marrow in a male B6C3F1 mouse from a subchronic study (higher magnification of Figure 5). The marrow space is largely devoid of hematopoietic cells and consists primarily of adipose tissue and vascular sinuses due to treatment-induced aplastic anemia.

    Authors

    Michelle C. Cora, DVM, DACVP
    Veterinary Medical Officer
    NTP Clinical Pathologist
    NTP Clinical Pathology Group
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC

    Gregory Travlos, DVM, DACVP
    Group Leader, Clinical Pathology Group
    Cellular and Molecular Pathology Branch
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC

    Reviewers

    Armando R. Irizarry, DVM, PHD, DACVP
    Adjunct Associate Professor of Veterinary Anatomic and Clinical Pathology
    Department of Comparative Pathobiology
    Purdue University College of Veterinary Medicine
    West Lafayette, IN

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC