Hepatobiliary System

Gallbladder, Epithelium - Hyperplasia

Narrative
Comment:
Figure 1 and Figure 2 are from a partially collapsed normal gallbladder. Note the thickness of the muscular wall. Gallbladder hyperplasia varies from a few cells on papillary folds to generalized papillary projections involving most of the mucosa (Figure 3 and Figure 4, arrows). Hyaline droplets may be present in the lining epithelium.
Recommendations:
Mucosal or epithelial hyperplasia of the gallbladder is uncommon in NTP studies and should be recorded whenever present and given a severity grade. Severe associated lesions such as inflammation or hyaline droplet accumulation should be diagnosed separately. The pathology narrative should define any unusual features of the case(s) being diagnosed.
References:

Greaves P. 2007. Histopathology of Preclinical Toxicity Studies: Interpretation and Relevance in Drug Safety Evaluation, 3rd ed. Elsevier, Amsterdam.

Abstract: http://www.sciencedirect.com/science/book/9780444527714

Harada T, Enomoto A, Boorman GA, Maronpot RR. 1999. Liver and gallbladder. In: Pathology of the Mouse: Reference and Atlas (Maronpot RR, Boorman GA, Gaul BW, eds). Cache River Press, Vienna, IL, 119-183.

Abstract: http://www.cacheriverpress.com/books/pathmouse.htm

Thoolen B, Maronpot RR, Harada T, Nyska A, Rousseaux C, Nolte T, Malarkey D, Kaufmann W, Kutter K, Deschl U, Nakae D, Gregson R, Winlove M, Brix A, Singl B, Belpoggi F, Ward JM. 2010. Hepatobiliary lesion nomenclature and diagnostic criteria for lesions in rats and mice (INHAND). Toxicol Pathol 38:5S-81S.

Full Text: http://tpx.sagepub.com/content/38/7_suppl/5S.full
  • Image of hyperplasia in the gallbladder epithelium from a male B6C3F1 mouse in a chronic study

    Epithelial hyperplasia in a male B6C3F1 mouse from a chronic study.

Enlarge Image
Enlarge All Images
<p>Epithelial hyperplasia in a male B6C3F1 mouse from a chronic study.</p>

Epithelial hyperplasia in a male B6C3F1 mouse from a chronic study.
<p>Epithelial hyperplasia in a male B6C3F1 mouse from a chronic study (higher magnification of Figure 1).</p>

Epithelial hyperplasia in a male B6C3F1 mouse from a chronic study (higher magnification of Figure 1).
<p>Epithelial hyperplasia-arrows indicate papillary hyperplasia in a male B6C3F1 mouse from a chronic study.</p>

Epithelial hyperplasia-arrows indicate papillary hyperplasia in a male B6C3F1 mouse from a chronic study.
<p>Epithelial hyperplasia-arrows indicate papillary hyperplasia in a male B6C3F1 mouse from a chronic study.</p>

Epithelial hyperplasia-arrows indicate papillary hyperplasia in a male B6C3F1 mouse from a chronic study.

Author

Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
Senior Pathologist
Experimental Pathology Laboratories, Inc.
Research Triangle Park, NC

Reviewers

John Cullen, VMD, PhD, DACVP, FIATP
Anatomic Pathology, Professor
North Carolina State University College of Veterinary Medicine
Raleigh, NC

David E. Malarkey DVM, PhD, DACVP, FIATP
Head, National Toxicology Program Pathology Group
Cellular and Molecular Pathology Branch
Division of the National Toxicology Program
National Institute of Environmental Health Sciences
Research Triangle Park, NC