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Liver - Angiectasis

Image of angiectasis in the liver from a female F344/N rat in a chronic study
Angiectasis in a female F344/N rat from a chronic study.
Figure 1 of 3
Image of angiectasis in the liver from a female F344/N rat
Angiectasis in a female F344/N rat from a diet restriction study.
Figure 2 of 3
Image of angiectasis in the liver from a female F344/N rat
Angiectasis in a female F344/N rat from a diet restriction study (higher magnification of Figure 2).
Figure 3 of 3
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comment:

Focal and multifocal angiectasis ( Figure 1image opens in a pop-up window and Figure 2image opens in a pop-up window ) occurs spontaneously, and more frequently as animals age, but it can also be caused by chemicals such as nitrosamines. It consists of dilated sinusoidal spaces that are lined by normal-appearing endothelial cells ( Figure 3image opens in a pop-up window ). In larger dilated spaces, endothelial cells may multiply to line the dilated spaces. Hepatocytes adjacent to angiectatic spaces may be normal or slightly atrophic. Angiectasis is distinguished from cystic degeneration by the presence of erythrocytes in endothelial-lined channels. The distinction between marked cases of angiectasis and hemangioma is often unclear.

recommendation:

Angiectasis should be documented and graded whenever present as an independent event but should not be diagnosed if it is associated with another lesion, such as a focus or a neoplasm. The number of dilated spaces and their degree of dilation will influence grading. Any indication of treatment-induced angiectasis should be recorded, graded, and described in the pathology narrative.

references:

Eustis SL, Boorman GA, Harada T, Popp JA. 1990. Liver. In: Pathology of the Fischer Rat (Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, 71-94.
Abstract: http://www.ncbi.nlm.nih.gov/nlmcatalog/9002563

Evans JG, Lake BG. 1998. The digestive system II. Hepatobiliary system. In: Target Organ Pathology (Turton J, Hooson J, eds). Taylor and Francis, London, 61-98.
Abstract: http://www.amazon.com/Target-Organ-Pathology-Basic-Text/dp/0748401571

Greaves P. 2007. Histopathology of Preclinical Toxicity Studies: Interpretation and Relevance in Drug Safety Evaluation, 3rd ed. Elsevier, Amsterdam.
Abstract: http://www.sciencedirect.com/science/book/9780444527714

Harada T, Enomoto A, Boorman GA, Maronpot RR. 1999. Liver and gallbladder. In: Pathology of the Mouse: Reference and Atlas (Maronpot RR, Boorman GA, Gaul BW, eds). Cache River Press, Vienna, IL, 119-183.
Abstract: http://www.cacheriverpress.com/books/pathmouse.htm

Hardisty JF, Brix AE. 2005. Comparative hepatic toxicity: Prechronic/chronic liver toxicity in rodents. Toxicol Pathol 33:35-40.
Full Text: http://tpx.sagepub.com/content/33/1/35.full.pdf

Haschek WM, Rousseaux CG, Wallig MA. 2010. Fundamentals of Toxicologic Pathology, 2nd ed. Academic Press, San Diego, 197-235.
Abstract: http://www.sciencedirect.com/science/book/9780123704696

National Toxicology Program. 2010. NTP TR-557. Toxicology and Carcinogenesis Studies of ß-Myrcene (CAS No. 123-35-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies). NTP, Research Triangle Park, NC.
Full Text: http://ntp.niehs.nih.gov/ntp/htdocs/LT_rpts/TR557.pdf

Thoolen B, Maronpot RR, Harada T, Nyska A, Rousseaux C, Nolte T, Malarkey D, Kaufmann W, Kutter K, Deschl U, Nakae D, Gregson R, Winlove M, Brix A, Singl B, Belpoggi F, Ward JM. 2010. Hepatobiliary lesion nomenclature and diagnostic criteria for lesions in rats and mice (INHAND). Toxicol Pathol 38:5S-81S.
Full Text: http://tpx.sagepub.com/content/38/7_suppl/5S.full

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.