Liver, Bile Duct - Cyst
comment:Single and multiloculated biliary cysts can occur spontaneously in older rats and mice. They can occur as single dilated biliary structures, multiple adjacent dilated biliary structures ( Figure 1 and Figure 2 ), or a multiloculated cyst ( Figure 3 ). Biliary cysts may accompany hepatic toxicity and may be associated with peripheral or sub-basilar collagen deposition ( Figure 4 ). They are typically lined by a single layer of flattened or low cuboidal epithelium ( Figure 4 ), with little evidence of active proliferation. In contrast to cholangiomas, they do not compress the adjacent hepatic parenchyma.
recommendation:Small biliary cysts may occasionally be seen in untreated rats but are more often associated with treatment. Consequently, they should be documented whenever present and given a severity grade.
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Harada T, Enomoto A, Boorman GA, Maronpot RR. 1999. Liver and gallbladder. In: Pathology of the Mouse: Reference and Atlas (Maronpot RR, Boorman GA, Gaul BW, eds). Cache River Press, Vienna, IL, 119-183. Abstract: http://www.cacheriverpress.com/books/pathmouse.htm
National Toxicology Program. 2006. NTP TR-521. Toxicology and Carcinogenesis Studies of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) (CAS No. 1746-01-6) in Female Harlan Sprague-Dawley Rats (Gavage Studies). NTP, Research Triangle Park, NC. Full Text: http://ntp.niehs.nih.gov/ntp/htdocs/LT_rpts/TR521.pdf
Thoolen B, Maronpot RR, Harada T, Nyska A, Rousseaux C, Nolte T, Malarkey D, Kaufmann W, Kutter K, Deschl U, Nakae D, Gregson R, Winlove M, Brix A, Singl B, Belpoggi F, Ward JM. 2010. Hepatobiliary lesion nomenclature and diagnostic criteria for lesions in rats and mice (INHAND). Toxicol Pathol 38:5S-81S. Full Text: http://tpx.sagepub.com/content/38/7_suppl/5S.full
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