Liver, Bile Duct - Cyst
comment:Single and multiloculated biliary cysts can occur spontaneously in older rats and mice. They can occur as single dilated biliary structures, multiple adjacent dilated biliary structures ( Figure 1 and Figure 2 ), or a multiloculated cyst ( Figure 3 ). Biliary cysts may accompany hepatic toxicity and may be associated with peripheral or sub-basilar collagen deposition ( Figure 4 ). They are typically lined by a single layer of flattened or low cuboidal epithelium ( Figure 4 ), with little evidence of active proliferation. In contrast to cholangiomas, they do not compress the adjacent hepatic parenchyma.
recommendation:Small biliary cysts may occasionally be seen in untreated rats but are more often associated with treatment. Consequently, they should be documented whenever present and given a severity grade.
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National Toxicology Program. 2006. NTP TR-521. Toxicology and Carcinogenesis Studies of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) (CAS No. 1746-01-6) in Female Harlan Sprague-Dawley Rats (Gavage Studies). NTP, Research Triangle Park, NC. Full Text: http://ntp.niehs.nih.gov/ntp/htdocs/LT_rpts/TR521.pdf
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