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Liver, Bile Duct - Cyst

Image of cyst in the liver bile duct from a female Harlan Sprague-Dawley rat in a chronic study
Bile duct cysts in a female Harlan Sprague-Dawley rat from a chronic study.
Figure 1 of 4
Image of cyst in the liver bile duct from a female Harlan Sprague-Dawley rat in a chronic study
Bile duct cysts in a female Harlan Sprague-Dawley rat from a chronic study (higher magnification of Figure 1).
Figure 2 of 4
Image of cyst in the liver bile duct from a female Harlan Sprague-Dawley rat in a chronic study
Bile duct cyst-multiloculated cyst in a female Harlan Sprague-Dawley rat from a chronic study.
Figure 3 of 4
Image of cyst in the liver bile duct from a female Harlan Sprague-Dawley rat in a chronic study
Bile duct cysts in a female Harlan Sprague-Dawley rat from a chronic study.
Figure 4 of 4
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comment:

Single and multiloculated biliary cysts can occur spontaneously in older rats and mice. They can occur as single dilated biliary structures, multiple adjacent dilated biliary structures ( Figure 1image opens in a pop-up window and Figure 2image opens in a pop-up window ), or a multiloculated cyst ( Figure 3image opens in a pop-up window ). Biliary cysts may accompany hepatic toxicity and may be associated with peripheral or sub-basilar collagen deposition ( Figure 4image opens in a pop-up window ). They are typically lined by a single layer of flattened or low cuboidal epithelium ( Figure 4image opens in a pop-up window ), with little evidence of active proliferation. In contrast to cholangiomas, they do not compress the adjacent hepatic parenchyma.

recommendation:

Small biliary cysts may occasionally be seen in untreated rats but are more often associated with treatment. Consequently, they should be documented whenever present and given a severity grade.

references:

Eustis SL, Boorman GA, Harada T, Popp JA. 1990. Liver. In: Pathology of the Fischer Rat (Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, 71-94.

Harada T, Enomoto A, Boorman GA, Maronpot RR. 1999. Liver and gallbladder. In: Pathology of the Mouse: Reference and Atlas (Maronpot RR, Boorman GA, Gaul BW, eds). Cache River Press, Vienna, IL, 119-183.
Abstract: http://www.cacheriverpress.com/books/pathmouse.htm

National Toxicology Program. 2006. NTP TR-521. Toxicology and Carcinogenesis Studies of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) (CAS No. 1746-01-6) in Female Harlan Sprague-Dawley Rats (Gavage Studies). NTP, Research Triangle Park, NC.
Full Text: http://ntp.niehs.nih.gov/ntp/htdocs/LT_rpts/TR521.pdf

Thoolen B, Maronpot RR, Harada T, Nyska A, Rousseaux C, Nolte T, Malarkey D, Kaufmann W, Kutter K, Deschl U, Nakae D, Gregson R, Winlove M, Brix A, Singl B, Belpoggi F, Ward JM. 2010. Hepatobiliary lesion nomenclature and diagnostic criteria for lesions in rats and mice (INHAND). Toxicol Pathol 38:5S-81S.
Full Text: http://tpx.sagepub.com/content/38/7_suppl/5S.full