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Liver - Cholangiofibrosis

Image of cholangiofibrosis in the liver from a female Harlan Sprague-Dawley rat in a chronic study
Cholangiofibrosis-arrows indicate incompletely lined proliferating bile ducts in a female Harlan Sprague-Dawley rat in a chronic study.
Figure 1 of 3
Image of cholangiofibrosis in the liver from a female Harlan Sprague-Dawley rat in a chronic study
Cholangiofibrosis in a female Harlan Sprague-Dawley rat from a chronic study.
Figure 2 of 3
Image of cholangiofibrosis in the liver from a male  F344/N rat in a subchronic study
Cholangiofibrosis in a male F344/N rat from a subchronic study.
Figure 3 of 3
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This chronic inflammatory process is initially associated with oval cell proliferation and bile duct hyperplasia with dilation of proliferating bile ducts. Bile duct contents include mucus, necrotic debris, and desquamated epithelial cells ( Figure 3image opens in a pop-up window ). Biliary structures are frequently incompletely lined (crescent-shaped bile ducts; Figure 1image opens in a pop-up window , arrows) by hyperchromatic cuboidal to columnar cells and goblet cells (intestinal metaplasia). As the lesion progresses, there is peribiliary fibrosis and a mixed inflammatory cell infiltrate ( Figure 1image opens in a pop-up window and Figure 2image opens in a pop-up window ). Large areas of hepatic lobe may be affected, with progressive resolution of lesions by development of sclerotic connective tissue, with retention of some biliary glandular acini and residual pools of mucus. Cholangiofibrosis may resemble cholangiocarcinoma but may be differentiated by the latter’s more prominent biliary epithelial changes (e.g., multiple layers or piling up of epithelial cells and pleomorphism). Epithelial cell atypia and increased mitotic figures may be present in either lesion, however, and therefore are not useful in differentiating cholangiofibrosis from cholangiocarcinoma. Some references indicate that significant bile duct dilation and intestinal metaplasia of the biliary epithelium are not prominent features of cholangiocarcinoma.


This inflammatory hepatic response should be documented and given a severity grade, with severity dependent on the extent of liver involvement. All the features described above are included in the diagnosis of cholangiofibrosis and should not be diagnosed separately unless they clearly represent separate processes.

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Liver - Inflammation


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Abstract: https://www.ncbi.nlm.nih.gov/pubmed/21177527

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Abstract: https://www.ncbi.nlm.nih.gov/pubmed/15805068

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Sirica AE. 1992. The Role of Cell Types in Hepatocarcinogenesis. CRC Press, Boca Raton, FL.
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Full Text: http://tpx.sagepub.com/content/38/7_suppl/5S.full