Liver - Cholangiofibrosis
comment:
This chronic inflammatory process is initially associated with oval cell proliferation and bile duct hyperplasia with dilation of proliferating bile ducts. Bile duct contents include mucus, necrotic debris, and desquamated epithelial cells ( Figure 3



recommendation:
This inflammatory hepatic response should be documented and given a severity grade, with severity dependent on the extent of liver involvement. All the features described above are included in the diagnosis of cholangiofibrosis and should not be diagnosed separately unless they clearly represent separate processes.related links:
Liver - Inflammationreferences:
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Bannasch P, Zerban H. 1990 Tumours of the liver. In: Pathology of Tumours in Laboratory Animals, Vol 1: Tumours of the Rat, 2nd ed. (Turusov VS, Mohr U, eds). IARC Scientific Publication No. 99. International Agency for Research on Cancer, Lyon, France, 199-240.
Eustis SL, Boorman GA, Harada T, Popp JA. 1990. Liver. In: Pathology of the Fischer Rat (Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, 71-94.
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Kimbrough RD, Linder RE, Burse VW, Jennings RW. 1973. Adenofibrosis in the rat liver, with persistence of polychlorinated biphenyls in adipose tissue. Arch Environ Health 27:390-395. Abstract: https://www.ncbi.nlm.nih.gov/pubmed/4356600
Sirica AE. 1992. The Role of Cell Types in Hepatocarcinogenesis. CRC Press, Boca Raton, FL. Abstract: http://www.crcpress.com/product/isbn/9780849347467
Thoolen B, Maronpot RR, Harada T, Nyska A, Rousseaux C, Nolte T, Malarkey D, Kaufmann W, Kutter K, Deschl U, Nakae D, Gregson R, Winlove M, Brix A, Singl B, Belpoggi F, Ward JM. 2010. Hepatobiliary lesion nomenclature and diagnostic criteria for lesions in rats and mice (INHAND). Toxicol Pathol 38:5S-81S. Full Text: http://tpx.sagepub.com/content/38/7_suppl/5S.full
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