Hepatobiliary System

Liver - Fatty Change

    Narrative
    Fatty change-focal fatty change (arrow) in a B6C3F1 male mouse from a chronic study.
    Fatty change-focal fatty change in a B6C3F1 male mouse from a chronic study (higher magnification of Figure 1).
    Fatty change-macrovesicular fatty change in a male F344/N rat from a chronic study.
    Fatty change-macrovesicular fatty change in a male F344/N rat from a chronic study (higher magnification of Figure 3).
    Fatty change-microvesicular fatty change in a male P53+/- (C57Bl/6) mouse from a chronic study.
    Fatty change-microvesicular fatty change in a male P53+/- (C57Bl/6) mouse from a chronic study (higher magnification of Figure 5).
    Fatty change-hepatocyte cytoplasmic vacuolation consistent with glycogen and macrovesicular fatty change in a male B6C3F1 mouse from a chronic study.
    Fatty change-hepatocyte cytoplasmic vacuolation consistent with glycogen and macrovesicular fatty change in a male B6C3F1 mouse from a chronic study (higher magnification of Figure 7).

    Author

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Reviewers

    John Cullen, VMD, PhD, DACVP, FIATP
    Anatomic Pathology, Professor
    North Carolina State University College of Veterinary Medicine
    Raleigh, NC

    David E. Malarkey DVM, PhD, DACVP, FIATP
    Head, National Toxicology Program Pathology Group
    Cellular and Molecular Pathology Branch
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC