Liver, Hepatocyte - Karyomegaly
comment:
Though karyomegaly is predominantly a nuclear change, Figure 1

recommendation:
While some degree of nuclear enlargement is frequently seen in mice, particularly as an aging change, the degree of nuclear enlargement and the accompanying enlargement of hepatocytes shown in Figure 1

references:
Epstein CJ. 1967. Cell size, nuclear content, and the development of polyploidy in the mammalian liver. Proc Natl Acad Sci USA 57:327-334. Full Text: http://www.pnas.org/content/57/2/327.full.pdf
Harada T, Enomoto A, Boorman GA, Maronpot RR. 1999. Liver and gallbladder. In: Pathology of the Mouse: Reference and Atlas (Maronpot RR, Boorman GA, Gaul BW, eds). Cache River Press, Vienna, IL, 119-183. Abstract: http://www.cacheriverpress.com/books/pathmouse.htm
Inamdar NB. 1958. Development of polyploidy in mouse liver. J Morphol 103:65-90. Abstract: http://onlinelibrary.wiley.com/doi/10.1002/jmor.1051030104/abstract
James J. 1977. The genesis of polyploidy in rat liver parenchymal cells. Eur J Cell Biol 15:410-419. Abstract: http://link.springer.com/article/10.1007%2FBF00482955
Lu MH, Hinson WG, He D, Turturro A, Hart RW. 1993. Hepatic nuclear ploidy distribution of dietary-restricted mice. Environ Health Perspect 101:229-233. Abstract: https://www.ncbi.nlm.nih.gov/pubmed/8013412
National Toxicology Program. 1993. NTP TR-394. Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies). NTP, Research Triangle Park, NC. Full Text: https://ntp.niehs.nih.gov/ntp/htdocs/LT_rpts/tr394.pdf
Styles JA. 1993. Measurement of ploidy and cell proliferation in the rodent liver. Environ Health Perspect 101(suppl 5):67-71. Abstract: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1519461/
Thoolen B, Maronpot RR, Harada T, Nyska A, Rousseaux C, Nolte T, Malarkey D, Kaufmann W, Kutter K, Deschl U, Nakae D, Gregson R, Winlove M, Brix A, Singl B, Belpoggi F, Ward JM. 2010. Hepatobiliary lesion nomenclature and diagnostic criteria for lesions in rats and mice (INHAND). Toxicol Pathol 38:5S-81S. Full Text: http://tpx.sagepub.com/content/38/7_suppl/5S.full
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