Hepatobiliary System

Liver - Necrosis

    Narrative
    Necrosis-sharply demarcated centrilobular necrosis in a male B6C3F1 mouse from a subchronic study.
    Necrosis-sharply demarcated centrilobular necrosis in a male B6C3F1 mouse from a subchronic study.
    Necrosis-patchy areas of coagulation necrosis in a female Swiss Webster mouse from a subchronic study.
    Necrosis-patchy areas of coagulation necrosis in a female Swiss Webster mouse from a subchronic study (higher magnification of Figure 3).
    Necrosis-hemorrhagic necrosis in a Swiss CD-1 mouse from an 18-month study.
    Necrosis-hemorrhagic necrosis in a Swiss CD-1 mouse from an 18-month study.
    Necrosis-focal necrosis with fatty change in a male B6C3F1 mouse from a chronic study.
    Necrosis-focal necrosis with fatty change in a male B6C3F1 mouse from a chronic study (higher magnification of Figure 9).
    Necrosis-hepatocyte necrosis accompanied by hepatocyte degeneration in a male B6C3F1 mouse from a subchronic study.
    Necrosis-hepatocyte necrosis accompanied by hepatocyte degeneration in a male B6C3F1 mouse from subchronic study (higher magnification of Figure 11).

    Author

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Reviewers

    John Cullen, VMD, PhD, DACVP, FIATP
    Anatomic Pathology, Professor
    North Carolina State University College of Veterinary Medicine
    Raleigh, NC

    David E. Malarkey DVM, PhD, DACVP, FIATP
    Head, National Toxicology Program Pathology Group
    Cellular and Molecular Pathology Branch
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC