Lymph Node - Apoptosis, Lymphocyte

comment:
Lymphocyte apoptosis is characterized by cell shrinkage, nuclear pyknosis, and fragmentation of lymphocytes into membrane-bound (apoptotic) bodies that are subsequently phagocytized by macrophages (tingible-body macrophages) ( Figure 1



recommendation:
Lymphocyte apoptosis in the lymph node can be normal. If increased compared with concurrent controls, lymphocyte apoptosis should be diagnosed and assigned a severity grade.references:
Elmore SA. 2006. Enhanced histopathology of the lymph nodes. Toxicol Pathol 34:634-647. Full Text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1783683/
Elmore SA. 2006. Histopathology of the lymph nodes. Toxicol Pathol 34:425-454. Full Text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892634/
Frith CH, Ward JM, Chandra M, Losco PE. 2000. Non-proliferative lesions of the hematopoietic system in rats. In: Guides for Toxicologic Pathology.TP/ARP/AFIP, Washington, DC. Full Text: https://www.toxpath.org/docs/SSNDC/HematopoieticNonprolifRat.pdf
National Toxicology Program. 2011. NTP TR-536. Toxicology and Carcinogenesis Studies of Bis(2-chloroethoxy)methane (CAS No. 111-91-1) in Rats and B6C3F1 Mice (Dermal Studies). NTP, Research Triangle Park, NC. Abstract: https://ntp.niehs.nih.gov/go/34791
Web page last updated on: January 27, 2015