Lymph Node - Atrophy

comment:
Lymph node atrophy may result from any toxic insult or disease that causes lymphocyte necrosis or apoptosis. Changes may include depletion of paracortical lymphocytes ( Figure 1


recommendation:
Lymph node atrophy should be diagnosed and graded unless it is determined to be age related. Plane of section and location should also be considered when evaluating the lymph nodes.references:
Elmore SA. 2006. Enhanced histopathology of the lymph nodes. Toxicol Pathol 34:634-647. Full Text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1783683/
Elmore SA. 2006. Histopathology of the lymph nodes. Toxicol Pathol 34:425-454. Full Text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892634/
Frith CH, Ward JM, Chandra M, Losco PE. 2000. Non-proliferative lesions of the hematopoietic system in rats. In: Guides for Toxicologic Pathology.TP/ARP/AFIP, Washington, DC. Full Text: https://www.toxpath.org/docs/SSNDC/HematopoieticNonprolifRat.pdf
National Toxicology Program. 2004. 13-Week Study (No. C20306) of PCN 66/67 (CAS No. PCNCOMPARISN) in F344 Rats and Sprague-Dawley Rats (Gavage Studies). NTP, Research Triangle Park, NC.
Stefanski SA, Elwell MR, Stromberg PC. 1990. Spleen, lymph nodes, and thymus. In: Pathology of the Fischer Rat: Reference and Atlas (Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, 369-394.
Ward JM, Mann PC, Morishima H, Frith CH. 1999. Thymus, spleen, and lymph nodes. In: Pathology of the Mouse (Maronpot RR, ed). Cache River Press, Vienna, IL, 333-360.
Web page last updated on: January 28, 2015