Lymph Node - Hyperplasia, Lymphocyte



comment:
In rodents, lymphocyte hyperplasia may involve various anatomical compartments of the lymph nodes, including the B-cell–rich follicles (follicular), the T-cell-rich paracortex (paracortical), the medullary cords, or all three. Follicular hyperplasia is identified by an increase in number and size of primary follicles and sometimes includes stimulation that results in secondary follicles (germinal centers). Stimulated germinal centers contain large lymphoblasts (centroblasts) and increased lymphocyte apoptosis with tingible-body macrophages. Paracortical lymphocyte hyperplasia is identified by increased cell density, occasionally accompanied by increased area ( Figure 1


recommendation:
Whenever present, lymphocyte hyperplasia of lymph nodes should be diagnosed, localized (e.g., follicle, paracortex), and graded. Due to lymph node variability, lymphocyte hyperplasia should be diagnosed only after careful evaluation and comparison with concurrent controls. Adequacy of the section (i.e., superficial or tangential) must be taken into consideration in the diagnosis of this lesion. For some lymph nodes (e.g., popliteal), an adequate section may be difficult to obtain.references:
Elmore SA. 2006. Enhanced histopathology of the lymph nodes. Toxicol Pathol 34:634-647. Full Text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1783683/
Elmore SA. 2006. Histopathology of the lymph nodes. Toxicol Pathol 34:425-454. Full Text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892634/
Frith CH, Ward JM, Chandra M, Losco PE. 2000. Non-proliferative lesions of the hematopoietic system in rats. In: Guides for Toxicologic Pathology.TP/ARP/AFIP, Washington, DC. Full Text: https://www.toxpath.org/docs/SSNDC/HematopoieticNonprolifRat.pdf
National Toxicology Program. 2008. NTP TR-546. Toxicology and Carcinogenesis Studies of Sodium Dichromate Dihydrate (CAS No. 7789-12-0) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies). NTP, Research Triangle Park, NC. Abstract: https://ntp.niehs.nih.gov/go/29323
Stefanski SA, Elwell MR, Stromberg PC. 1990. Spleen, lymph nodes, and thymus. In: Pathology of the Fischer Rat: Reference and Atlas (Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, 369-394.
Ward JM, Mann PC, Morishima H, Frith CH. 1999. Thymus, spleen, and lymph nodes. In: Pathology of the Mouse (Maronpot RR, ed). Cache River Press, Vienna, IL, 333-360.
Ward JM, Rehg JE, Morse HC III. 2012. Differentiation of rodent immune and hematopoietic system reactive lesions from neoplasia. Toxicol Pathol 40:425-434. Abstract: https://www.ncbi.nlm.nih.gov/pubmed/22215512
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