Spleen - Amyloid

comment:
Amyloidosis is a systemic disease characterized by the extracellular deposition of amorphous proteinaceous material in multiple tissues, including spleen, liver, and kidney. In the spleen of mice, amyloid is deposited in the red pulp and adjacent to the white pulp (marginal zone) ( Figure 1


recommendation:
Whenever present, amyloid in the spleen should be diagnosed and assigned a severity grade. Since amyloidosis is a systemic disease, other tissues, such as liver and kidney, should also be evaluated for amyloid. Secondary lesions, such as necrosis or degeneration of parenchymal cells, should not be diagnosed separately unless warranted by severity or important for interpretation of study results, but should be described in the pathology narrative.references:
Ge F, Yao J, Fu X, Guo Z, Yan J, Zhang B, Zhang H, Tomozawa H, Miyazaki J, Sawashita J, Mori M, Higuchi K. 2007. Amyloidosis in transgenic mice expressing murine amyloidogenic apolipoprotein A-II (Apoa2c). Lab Invest 87:633-643. Abstract: https://www.ncbi.nlm.nih.gov/pubmed/17468778
Harada T, Enomoto A, Boorman GA, Maronpot RR. 1999. Liver and gallbladder. In: Pathology of the Mouse (Maronpot RR, ed). Cache River Press, Vienna, IL, 119-183.
National Toxicology Program. 2010. NTP TR-558. Toxicology and Carcinogenesis Studies of 3,3′,4,4′-Tetrachloroazobenzene (TCAB) [CAS No. 14047-09-7] in Harlan Sprague-Dawley Rats and B6C3F1 Mice (Gavage Studies). NTP, Research Triangle Park, NC. Abstract: https://ntp.niehs.nih.gov/go/33564
Suttie AW. 2006. Histopathology of the spleen. Toxicol Pathol 34:466-503. Full Text: http://tpx.sagepub.com/content/34/5/466.full.pdf
Ward JM, Mann PC, Morishima H, Frith CH. 1999. Thymus, spleen, and lymph nodes. In: Pathology of the Mouse (Maronpot RR, ed). Cache River Press, Vienna, IL, 333-360.
Web page last updated on: January 27, 2015