Immune System

Spleen - Apoptosis, Lymphocyte

    Narrative
    Spleen - Apoptosis, Lymphocyte in a female B6C3F1/N mouse from a subchronic study. Tingible body macrophages are scattered throughout the splenic white pulp (arrows).
    Spleen - Apoptosis, Lymphocyte in a female B6C3F1/N mouse from a subchronic study (higher magnification of Figure 1). Tingible body macrophages (arrow) contain intracytoplasmic fragments of apoptotic lymphocytes (apoptotic bodies) (arrowhead).

    Authors

    Kristen Hobbie, DVM, PhD
    Principal Pathologist
    Huntingdon Life Sciences
    Peterborough, UK

    Susan A. Elmore, MS, DVM, DACVP, DABT, FIATP
    Staff Scientist, NTP Pathologist
    NTP Pathology Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC

    Holly M. Kolenda-Roberts, DVM, PhD, DACVP
    Veterinary Pathologist
    SNBL USA
    Everett, WA

    Reviewers

    Jerrold M. Ward, DVM, PhD, DACVP, FIATP
    Veterinary Pathologist
    Global VetPathology
    Montgomery Village, MD

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC