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    Image of atrophy in the spleen from a female F344/N rat in a subchronic study
    Spleen, White pulp - Atrophy in a female F344/N rat from a subchronic study. Overall area and cellularity of the white pulp (periarteriolar lymphatic sheaths and follicles) are decreased (arrows), although the marginal zones appear to be within normal limits.
    Image of atrophy in the spleen from a female F344/N rat in a subchronic study
    Spleen, White pulp - Atrophy in a female F344/N rat from a subchronic study (higher magnification of Figure 1). Decreased cellularity and area of the periarteriolar lymphatic sheath region (arrows) are evident.
    Image of atrophy in the spleen from a female B6C3F1/N mouse in a subchronic study
    Spleen - Atrophy in a female B6C3F1/N mouse from a subchronic study. Both red pulp (arrow) and white pulp (follicles, periarteriolar lymphatic sheaths, marginal zones) are atrophied.
    Image of atrophy in the spleen from a female B6C3F1/N mouse in a subchronic study
    Spleen - Atrophy in a female B6C3F1/N mouse from a subchronic study (higher magnification of Figure 3). In addition to white pulp atrophy, red pulp elements are decreased, and there is a moderate amount of pigment within the red pulp compartment (arrow).