Immune System

Spleen - Hemorrhage

    Narrative
    Spleen - Hemorrhage in a female Harlan Sprague-Dawley rat from a chronic study. A focal accumulation of extravasated erythrocytes resulted in protrusion of the splenic capsule (arrow).
    Spleen - Hemorrhage in a female Harlan Sprague-Dawley rat from a chronic study. A focal accumulation of extravasated erythrocytes resulted in protrusion of the splenic capsule (arrow).
    Spleen - Hemorrhage in a female F344/N rat from a chronic study. The splenic parenchyma is markedly expanded by extravasated erythrocytes (arrow).
    Spleen - Hemorrhage in a female F344/N rat from a chronic study. The splenic parenchyma is markedly expanded by extravasated erythrocytes (arrow).

    Authors

    Kristen Hobbie, DVM, PhD
    Principal Pathologist
    Huntingdon Life Sciences
    Peterborough, UK

    Susan A. Elmore, MS, DVM, DACVP, DABT, FIATP
    Staff Scientist, NTP Pathologist
    NTP Pathology Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC

    Holly M. Kolenda-Roberts, DVM, PhD, DACVP
    Veterinary Pathologist
    SNBL USA
    Everett, WA

    Reviewers

    Jerrold M. Ward, DVM, PhD, DACVP, FIATP
    Veterinary Pathologist
    Global VetPathology
    Montgomery Village, MD

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC