Spleen - Hemorrhage

comment:
Hemorrhage is characterized by the presence of extravasated erythrocytes within the splenic capsule ( Figure 1


recommendation:
Whenever present in the spleen, hemorrhage should be diagnosed and graded. Splenic hematomas should not be diagnosed separately but diagnosed as hemorrhage. Hemorrhage need not be diagnosed if secondary to splenic neoplasia but should be noted in the pathology narrative.references:
National Cancer Institute. 1979. NCI-CG-TR-153. Bioassay of o-Toluidine Hydrochloride for Possible Carcinogenicity (CAS No. 636-21-5) in F344/N Rats and B6C3F1 Mice (Feed Studies). NCI, Bethesda, MD. Abstract: https://ntp.niehs.nih.gov/go/10049
National Toxicology Program. 2010. NTP TR-559. Toxicology and Carcinogenesis of 2,3′,4,4′,5-Pentachlorobiphenyl (PCB 118) (CAS No. 31508-00-6) in Female Harlan Sprague-Dawley Rat (Gavage Studies). NTP, Research Triangle Park, NC. Abstract: https://ntp.niehs.nih.gov/go/33539
Stefanski SA, Elwell MR, Stromberg PC. 1990. Spleen, lymph nodes, and thymus. In: Pathology of the Fischer Rat: Reference and Atlas (Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, 369-394.
Ward JM, Mann PC, Morishima H, Frith CH. 1999. Thymus, spleen, and lymph nodes. In: Pathology of the Mouse (Maronpot RR, ed). Cache River Press, Vienna, IL, 333-360.
Web page last updated on: January 27, 2015