Spleen - Hyperplasia, Lymphocyte

comment:
Lymphocyte hyperplasia of the spleen is an increase in the number of lymphocytes outside the range of normal compared with concurrent controls. The result can be variable increases in the area and number of white pulp elements (periarteriolar lymphoid sheaths [PALS], follicles, and/or marginal zones) ( Figure 1




recommendation:
Whenever present, lymphocyte hyperplasia of the spleen should be diagnosed and assigned a severity grade. The number of lymphocytes in the spleen is often variable; therefore, the pathologist must carefully examine and determine the range of normal for a study by comparing with concurrent controls. The plane of section should also be taken into consideration (transverse, longitudinal, tangential, or shallow sections) when evaluating the spleen. Diagnosis should be based upon the pathologist’s best judgment.references:
Elmore SA. 2006. Enhanced histopathology of the spleen. Toxicol Pathol 34:648-655. Full Text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1828535/
National Toxicology Program. 2011. NTP TR-570. Toxicology and Carcinogenesis Studies of α,β-Thujone (CAS No. 76231-76-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies). NTP, Research Triangle Park, NC. Abstract: https://ntp.niehs.nih.gov/go/36137
Stefanski SA, Elwell MR, Stromberg PC. 1990. Spleen, lymph nodes, and thymus. In: Pathology of the Fischer Rat: Reference and Atlas (Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, 369-394.
Suttie AW. 2006. Histopathology of the spleen. Toxicol Pathol 34:466-503. Full Text: http://tpx.sagepub.com/content/34/5/466.full.pdf
Ward JM, Mann PC, Morishima H, Frith CH. 1999. Thymus, spleen, and lymph nodes. In: Pathology of the Mouse (Maronpot RR, ed). Cache River Press, Vienna, IL, 333-360.
Ward JM, Rehg JE, Morse HC III. 2012. Differentiation of rodent immune and hematopoietic system reactive lesions from neoplasias. Toxicol Pathol 40:425-434. Abstract: https://www.ncbi.nlm.nih.gov/pubmed/22215512
Web page last updated on: February 10, 2015