Spleen - Inflammation

comment:
Inflammation is an uncommon lesion in the spleen of rodents, and when present, infectious agents are the most likely cause ( Figure 1





recommendation:
When present, inflammatory lesions in the spleen should be diagnosed and graded. The inflammation should be categorized based on the predominant cell population present by adding the appropriate modifier to the diagnosis (acute, chronic active, etc.). The word "abscess" should be used as a gross diagnosis only; abscesses should be diagnosed as suppurative inflammation. Associated lesions, such as necrosis or hemorrhage, should not be diagnosed separately unless warranted by severity, but should be described in the pathology narrative. If the inflammation is secondary to another lesion, such as necrosis or neoplasia, it should not be diagnosed separately unless warranted by severity, but should be noted in the narrative.references:
National Toxicology Program. 1989. NTP TR-362. Toxicology and Carcinogenesis Studies of 4-Vinyl-1-Cyclohexene Diepoxide (CAS No. 106-87-6) in F344/N Rats and B6C3F1 Mice (Dermal Studies). NTP, Research Triangle Park, NC. Abstract: https://ntp.niehs.nih.gov/go/6985
National Toxicology Program. 1993. NTP TR-427. Toxicology and Carcinogenesis Studies of Turmeric Oleoresin (CAS No. 8024-37-1) (Major Component 79%-85% Curcumin, CAS No. 458-37-7) in F344/N Rats and B6C3F1 Mice (Feed Studies). NTP, Research Triangle Park, NC. Abstract: https://ntp.niehs.nih.gov/go/5998
Stefanski SA, Elwell MR, Stromberg PC. 1990. Spleen, lymph nodes, and thymus. In: Pathology of the Fischer Rat: Reference and Atlas (Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, 369-394.
Ward JM, Mann PC, Morishima H, Frith CH. 1999. Thymus, spleen, and lymph nodes. In: Pathology of the Mouse (Maronpot RR, ed). Cache River Press, Vienna, IL, 333-360.
Web page last updated on: February 03, 2015