Spleen - Necrosis - Gallery
Spleen - Necrosis in a male F344/N rat from a chronic study. A large necrotic focus (arrow) is present with the spleen.
Spleen - Necrosis in a male F344/N rat from a chronic study (higher magnification of Figure 1). Necrosis is bordered by foci of hemorrhage (arrowhead) and fibrous connective tissue (arrow).
Spleen - Necrosis in a male B6C3F1/N mouse from a chronic study. A large necrotic focus (arrow) is present with the spleen.
Spleen - Necrosis in a male B6C3F1/N mouse from a chronic study (higher magnification of Figure 3). The necrotic focus is bordered by a mixed inflammatory infiltrate (arrow), fibrosis (arrowhead), and dilated blood vessels.
Spleen - Necrosis in a male F344/N rat from a chronic study. A large necrotic focus is present within the splenic red pulp, with focal areas of associated hemorrhage (arrowhead) and bordered by an inflammatory infiltrate (arrow).
Spleen - Necrosis in a male F344/N rat from a chronic study (higher magnification of Figure 5). The necrotic focus consists of necrotic cellular debris, degenerate neutrophils, and hemorrhage (arrowhead) and is bordered by a rim of histiocytes, lymphocytes, and fibroblasts (arrow).
