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    Image of necrosis in the spleen from a male F344/N rat in a chronic study
    Spleen - Necrosis in a male F344/N rat from a chronic study. A large necrotic focus (arrow) is present with the spleen.
    Image of necrosis in the spleen from a male F344/N rat in a chronic study
    Spleen - Necrosis in a male F344/N rat from a chronic study (higher magnification of Figure 1). Necrosis is bordered by foci of hemorrhage (arrowhead) and fibrous connective tissue (arrow).
    Image of necrosis in the spleen from a male B6C3F1/N mouse in a chronic study
    Spleen - Necrosis in a male B6C3F1/N mouse from a chronic study. A large necrotic focus (arrow) is present with the spleen.
    Image of necrosis in the spleen from a male B6C3F1/N mouse in a chronic study
    Spleen - Necrosis in a male B6C3F1/N mouse from a chronic study (higher magnification of Figure 3). The necrotic focus is bordered by a mixed inflammatory infiltrate (arrow), fibrosis (arrowhead), and dilated blood vessels.
    Image of necrosis in the spleen from a male F344/N rat in a chronic study
    Spleen - Necrosis in a male F344/N rat from a chronic study. A large necrotic focus is present within the splenic red pulp, with focal areas of associated hemorrhage (arrowhead) and bordered by an inflammatory infiltrate (arrow).
    Image of necrosis in the spleen from a male F344/N rat in a chronic study
    Spleen - Necrosis in a male F344/N rat from a chronic study (higher magnification of Figure 5). The necrotic focus consists of necrotic cellular debris, degenerate neutrophils, and hemorrhage (arrowhead) and is bordered by a rim of histiocytes, lymphocytes, and fibroblasts (arrow).