Spleen - Necrosis
comment:Splenic necrosis ( Figure 1 , Figure 2 , Figure 3 , Figure 4 , Figure 5 , and Figure 6 ) may be induced experimentally in rodents; however, this lesion is more often associated with vascular obstruction, trauma, or neoplasia. Expansive necrosis can be associated with a thrombus or neoplasm in the spleen. Necrosis of splenic constituents is characterized by cell swelling, condensation and dissolution of the nucleus, and cell lysis with accumulation of abundant eosinophilic cytoplasmic and karyorrhectic nuclear debris. Inflammation, hemorrhage, fibrin, fibrosis, and/or mineralization may accompany splenic necrosis.
recommendation:Whenever present, necrosis of the spleen should be diagnosed and assigned a severity grade. If splenic necrosis is secondary to a lesion such as thrombus or neoplasia, it should not be diagnosed but should be described in the narrative. Secondary lesions, such as inflammation or hemorrhage, should not be diagnosed separately unless warranted by severity, but should be described in the pathology narrative.
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