Immune System

Thymus - Atypical Hyperplasia, Lymphocyte

    Narrative
    Thymus - Atypical hyperplasia, Lymphocyte in a female p53+/- (C57Bl/6) mouse from a subchronic study. When atypical lymphocyte hyperplasia is unilateral, the affected lobe (arrow) is typically smaller than the unaffected lobe.
    Thymus - Atypical hyperplasia, Lymphocyte in a female p53+/- (C57Bl/6) mouse from a subchronic study (higher magnification of Figure 1). Normal thymic architecture is replaced by a sheet of large, atypical lymphocytes, including lymphoblasts and fewer, admixed small lymphocytes.

    Authors

    Kristen Hobbie, DVM, PhD
    Principal Pathologist
    Huntingdon Life Sciences
    Peterborough, UK

    Susan A. Elmore, MS, DVM, DACVP, DABT, FIATP
    Staff Scientist, NTP Pathologist
    NTP Pathology Group
    National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC

    Holly M. Kolenda-Roberts, DVM, PhD, DACVP
    Veterinary Pathologist
    SNBL USA
    Everett, WA

    Reviewers

    Jerrold M. Ward, DVM, PhD, DACVP, FIATP
    Veterinary Pathologist
    Global VetPathology
    Montgomery Village, MD

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC