Thymus - Ectopic Tissue

comment:
Ectopic tissue is a fragment of structurally normal tissue (e.g., thyroid, parathyroid) in an abnormal location. This lesion can be congenital or the result of an injury. Ectopic thyroid tissue may occur in and/or adjacent to the thymus of rodents. The thyroid tissue shown in Figure 1

recommendation:
Ectopic tissue is typically an incidental finding in or adjacent to the thymus of rodents. When this lesion is present it should diagnosed but not graded. The type of ectopic tissue present (e.g., thyroid, parathyroid) should be included in the diagnosis as a modifier (e.g., Thymus - Ectopic tissue, Thyroid).references:
Brayton C. 2007. Spontaneous diseases in commonly used mouse strains. In: The Mouse in Biomedical Research: Diseases, 2nd ed (Fox JG, Barthold S, Davisson M, Newcomer CE, Quimby FW, Smith A, eds). Academic Press, Burlington, MA, 676.
National Toxicology Program. 1983. NTP TR-248. Carcinogenesis Studies of 4,4’-Methylenedianiline Dihydrochloride (CAS No. 13552-44-8) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies). NTP, Research Triangle Park, NC. Abstract: https://ntp.niehs.nih.gov/go/7104
Pearse G. 2006. Histopathology of the thymus. Toxicol Pathol 34:515-547. Full Text: http://tpx.sagepub.com/content/34/5/515.long
Stefanski SA, Elwell MR, Stromberg PC. 1990. Spleen, lymph nodes, and thymus. In: Pathology of the Fischer Rat: Reference and Atlas (Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, 369-394.
Ward JM, Mann PC, Morishima H, Frith CH. 1999. Thymus, spleen, and lymph nodes. In: Pathology of the Mouse (Maronpot RR, ed). Cache River Press, Vienna, IL, 333-360.
Web page last updated on: February 03, 2015