Integumentary System

Skin - Hyperplasia

    Narrative
    Normal skin in a male B6C3F1 mouse from a 90-day study.
    Epithelial hyperplasia-increased numbers of squamous cells in the epidermis (arrow) and follicular epithelium (arrowheads) in a female B6C3F1 mouse from a 90-day study.
    Sebaceous gland hyperplasia-increased numbers of sebocytes forming lobules around central ducts in a male F344/N rat from a 90-day study.
    Sebaceous gland hyperplasia-increased numbers of sebocytes forming lobules around central ducts in a male F344/N rat from a 90-day study.
    Follicular hyperplasia-increased numbers of follicular units within the dermis and subcutis in a female B6C3F1 mouse from a 90-day study.

    Authors

    Molly H. Boyle, DVM, MPH, DACVP
    Toxicologic Pathologist
    Integrated Laboratory Systems, Inc.
    Research Triangle Park, NC

    Georgette D. Hill, D.V.M., Ph.D.
    Toxicologic Pathologist
    Assistant Pathology Program Manager
    Integrated Laboratory Systems, Inc. Research Triangle Park, NC

    Reviewers

    Michael R. Elwell, DVM, PhD, DACVP
    Anatomic Pathologist
    Covance Laboratories, Inc.
    Washington, D.C.

    David E. Malarkey DVM, PhD, DACVP, FIATP
    Head, National Toxicology Program Pathology Group
    Cellular and Molecular Pathology Branch
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC