Skin - Pustule

Pustule-accumulations of neutrophils with the stratum corneum (arrows) in a male B6C3F1 mouse from a subchronic study.
Figure 1 of 2
comment:
Pustules ( Figure 1

recommendation:
Whenever present without apparent underlying erosion or ulceration, pustules should be diagnosed and assigned a severity grade based on size and number. Pustules may be seen with dermal inflammation, epidermal hyperplasia, or hyperkeratosis, all of which should be recorded as separate diagnoses. If pustules are seen concurrently with erosions/ulcers, then both diagnoses should be recorded and graded.references:
Klein-Szanto AJP, Conti CJ. 2002. Skin and oral mucosa. In: Handbook of Toxicologic Pathology, 2nd ed (Haschek WM, Rousseaux CG, Wallig MA, eds). Academic Press, San Diego, 2:85-116. Abstract: http://www.sciencedirect.com/science/book/9780123302151
National Toxicology Program. 1999. NTP TR 449. Toxicology and Carcinogenesis Studies of Triethanolamine (CAS No. 102-71-6) in F344/N Rats and B6C3F1 Mice (Dermal Studies). NTP, Research Triangle Park, NC. Full Text: https://ntp.niehs.nih.gov/ntp/htdocs/LT_rpts/tr449.pdf
Web page last updated on: January 02, 2014