Skin - Vesicle
comment:Vesicles are small, circumscribed, subcorneal (intraepidermal) or subepidermal cystlike spaces that contain serous fluid ( Figure 1 ). They represent detachment of damaged epithelium with the resulting space being filled by fluid. Vesicles may form after exposure to caustic agents. They may also form as part of an allergic response in the skin in which edema and congestion are seen initially, followed eventually by vesicle formation. Vesicles typically occur in the initial stages of acute inflammation after skin injury but are not often present at the end of a study. Consequently, they are a relatively rare finding.
recommendation:Because they can provide information regarding the severity of a response to a test agent, or they may suggest an allergic type of response, vesicles should be recorded and graded whenever present. Grading should be based on size and number. Other associated lesions in the skin, such as inflammation or necrosis, should be diagnosed separately.
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