Skin - Vesicle
comment:
Vesicles are small, circumscribed, subcorneal (intraepidermal) or subepidermal cystlike spaces that contain serous fluid ( Figure 1
recommendation:
Because they can provide information regarding the severity of a response to a test agent, or they may suggest an allergic type of response, vesicles should be recorded and graded whenever present. Grading should be based on size and number. Other associated lesions in the skin, such as inflammation or necrosis, should be diagnosed separately.references:
Elwell MR, Stedman MA, Kovatch RM. 1990. Skin and subcutis. In: Pathology of the Fischer Rat: Reference and Atlas (Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, 261-277. Abstract: http://www.ncbi.nlm.nih.gov/nlmcatalog/9002563
Klein-Szanto AJP, Conti CJ. 2002. Skin and oral mucosa. In: Handbook of Toxicologic Pathology, 2nd ed (Haschek WM, Rousseaux CG, Wallig MA, eds). Academic Press, San Diego, 2:85-116. Abstract: http://www.sciencedirect.com/science/book/9780123302151
Peckham JC, Heider K. 1999. Skin and subcutis. In: Pathology of the Mouse: Reference and Atlas (Maronpot RR, Boorman GA, Gaul BW, eds). Cache River Press, Vienna, IL, 555-612. Abstract: http://www.cacheriverpress.com/books/pathmouse.htm
Web page last updated on: January 02, 2014