Coagulating Gland - Hyperplasia


comment:
Hyperplasia of the coagulating gland consists of proliferation of the lining epithelium. The cells may pile up (arrows, Figure 1



recommendation:
Hyperplasia should be graded and recorded, with qualification as bilateral when both coagulating glands are affected. Severity should be based on the more severely affected gland. Correlations with similar changes that may be present in other accessory sex gland should be mentioned in the pathology narrative.references:
Arai Y, Suzuki Y, Nishizuka Y. 1977. Hyperplastic and metaplastic lesions in the reproductive tract of male rats induced by neonatal treatment with diethylstilbestrol. Virchows Arch A Pathol Anat Histol 376:21-28. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/145081
Bosland MC, Tuomari DL, Elwell MR, Shirai T, Ward JM, McConnell RF. 1998. Proliferative lesions of the prostate and other accessory sex glands in male rats, URG-4. In: Guidelines for Toxicologic Pathology. STP/ARP/AFIP, Washington, DC, 1-20.
Creasy D, Bube A, de Rijk E, Kandori H, Kuwahara M, Masson R, Nolte T, Reams R, Regan K, Rehm S, Rogerson P, Whitney K. 2012. Proliferative and nonproliferative lesions of the rat and mouse male reproductive system. Toxicol Pathol 40:40S-121S. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22949412
Pylkkanen L, Santti R, Newbold R, McLachlan JA. 1991. Regional differences in the prostate of the neonatally estrogenized mouse. Prostate 18:117-129. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/2006118
Radovsky A, Mitsumori K, Chapin RE. 1999. Male reproductive tract. In: Pathology of the Mouse: Reference and Atlas (Maronpot RR, Boorman GA, Gaul BW, eds). Cache River Press, Vienna, IL, 381-407. Abstract: http://www.cacheriverpress.com/books/pathmouse.htm
Strauss L, Makela S, Joshi S, Huhtaniemi I, Santti R. 1998. Genistein exerts estrogen-like effects in male mouse reproductive tract. Mol Cell Endocrinol 144:83-93. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/9863629
Suwa T, Nyska A, Haseman JK, Mahler JF, Maronpot RR. 2002. Spontaneous lesions in control B6C3F1 mice and recommended sectioning of male accessory sex organs. Toxicol Pathol 30(2):228- 234. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/11950166
Web page last updated on: August 19, 2014