U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Skip to Main Navigation
Skip to Page Content
Skip to Atlas Navigation

Epididymis - Amyloid

Image of amyloid in the epididymis from a male B6C3F1 mouse in a chronic study
Epididymis - Amyloid. Amyloid deposits in the interstitium (arrows) in a male B6C3F1 mouse from a chronic study.
Figure 1 of 2
Image of amyloid in the epididymis from a male B6C3F1 mouse in a chronic study
Epididymis - Amyloid. Higher magnification of Figure 1. Amyloid deposits in the interstitium (arrows) in a male B6C3F1 mouse from a chronic study.
Figure 2 of 2
next arrow

comment:

Amyloidosis is an age-related, incidental background finding most commonly seen in mice. It is generally a systemic condition, but the epididymis is a common site for deposition. It appears as pale, eosinophilic extracellular material that has a green birefringence under polarized light when stained with Congo red.

recommendation:

Amyloid should be recorded and graded and should be discussed in the pathology narrative if the incidence and/or severity appear to be related to chemical administration. Associated or secondary lesions need not be diagnosed unless warranted by their severity.

references:

Radovsky A, Mitsumori K, Chapin RE. 1999. Male reproductive tract. In: Pathology of the Mouse: Reference and Atlas (Maronpot RR, Boorman GA, Gaul BW, eds). Cache River Press, Vienna, IL, 381-407.