Epididymis, Epithelium - Vacuolation


comment:
The epididymal epithelium develops many different forms of vacuolation. They are often segmental and region specific. The vacuolation may be the result of a number of degenerative processes, including the accumulation of lipids, phospholipids (phospholipidosis), glycoproteins, or fluids. The vacuoles may be or large (macrovacuolation, Figure 1



recommendation:
Vacuolation of the epithelium should be recorded and graded and should be discussed in the pathology narrative if the incidence and/or severity appears to be related to chemical administration. The type and location of the vacuolation should be noted if it appears specific and noteworthy. Diagnosis should indicate if the change is bilateral. Correlation with disturbances in other male reproductive organs is recommended to aid interpretation.references:
Boorman GA, Chapin RE, Mitsumori K. 1990. Testis and epididymis. In: Pathology of the Fischer Rat: Reference and Atlas (Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, 405-418.
Creasy D, Bube A, de Rijk E, Kandori H, Kuwahara M, Masson R, Nolte T, Reams R, Regan K, Rehm S, Rogerson P, Whitney K. 2012. Proliferative and nonproliferative lesions of the rat and mouse male reproductive system. Toxicol Pathol 40:40S-121S. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22949412
Haines DC, Chattopadhyay S, Ward JM. 2001. Pathology of aging B6;129 mice. Toxicol Pathol 29:653-661. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/11794381
Robaire B. 2002. Aging of the epididymis. In: The Epididymis: From Molecules to Clinical (Robaire B, Hinton BT, eds). New York, Kluwer/Plenum, 285-296. Abstract: http://www.springer.com/medicine/urology/book/978-0-306-46684-7
Robaire B, Hinton BT, eds. 2002. The Epididymis: From Molecules to Clinical. Abstract: http://www.springer.com/medicine/urology/book/978-0-306-46684-7
Rudmann DG, McNerney ME, Vandereide SL, Schemmer JK, Eversole RR, Vonderfecht SL. 2004. Epididymal and systemic phospholipidosis in rats and dogs treated with the dopamine D3 selective antagonist PNU-177864. Toxicol Pathol 32:326-332. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/15204974
Stebbins KE, Bond DM, Novilla MN, Reasor MJ. 2002. Spinosad insecticide: Subchronic and chronic toxicity and lack of carcinogenicity in CD-1 mice. Toxicol Sci 65:276-287. Abstract: http://toxsci.oxfordjournals.org/content/65/2/276.abstract
Yano BL, Bond DM, Novilla MN, McFadden LG, Reasor MJ. 2002. Spinosad insecticide: Subchronic and chronic toxicity and lack of carcinogenicity in Fischer 344 rats. Toxicol Sci 65:288-298. Abstract: http://toxsci.oxfordjournals.org/content/65/2/288.abstract
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