Reproductive System, Male

Epididymis, Epithelium - Vacuolation

    Narrative
    Epididymis, Epithelium - Vacuolation. Numerous macrovesicular cytoplasmic vacuoles are present in the ductal epithelium in a male F344/N rat from a chronic study.
    Epididymis, Epithelium - Vacuolation. Microvesicular vacuolation is present in the epididymal duct cells of a rat. (Photograph courtesy of D. Creasy.)
    Epididymis, Epithelium - Clear cells. Clear cells in a male F344/N rat from a chronic study. Clear cells are a normal cell type responsible for endocytosis of luminal particulate matter and should not be confused with degenerative cytoplasmic vacuolation.

    Authors:

    Dianne M. Creasy, PhD, Dip RCPath, FRCPath
    Dianne Creasy Consulting LLC
    Pipersville, PA

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Dipak K. Giri, DVM, PhD, DACVP
    Toxicologic Pathologist
    Integrated Laboratory Systems, Inc.
    Research Triangle Park, NC

    Reviewers:

    Mark F. Cesta, DVM, PhD, DACVP
    Staff Scientist, NTP Pathologist
    Cellular and Molecular Pathology Branch
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC

    David E. Malarkey DVM, PhD, DACVP, FIATP
    Head, National Toxicology Program Pathology Group
    Cellular and Molecular Pathology Branch
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC