Epididymis - Spermatocele
comment:
Spermatoceles are cystic dilations of the epididymal duct (three or more times the diameter of the normal duct), which may be lined by hypertrophic or normal epithelium. They are most commonly seen in the initial segment or the caput region of the mouse epididymis (Figure 1) and are filled with varying amounts of sperm. Focal areas of mineralization are present within this spermatocele (arrows, Figure 1
recommendation:
Spermatoceles should be recorded as present and discussed in the pathology narrative if the incidence appears to be related to chemical administration. If present in both epididymides, the diagnosis should be qualified as bilateral. It is not necessary to grade spermatoceles.references:
Cooper ERA, Jackson H. 1973. Chemically induced sperm retention cysts in the rat. J Reprod Fertil 34:445-449. Abstract: http://www.popline.org/node/491769
Creasy D, Bube A, de Rijk E, Kandori H, Kuwahara M, Masson R, Nolte T, Reams R, Regan K, Rehm S, Rogerson P, Whitney K. 2012. Proliferative and nonproliferative lesions of the rat and mouse male reproductive system. Toxicol Pathol 40:40S-121S. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22949412
Frith CH, Ward JM. 1988. Color Atlas of Neoplastic and Non-neoplastic Lesions in Aging Mice. Elsevier, Amsterdam. Abstract: http://www.informatics.jax.org/frithbook/
Hess RA. 1998. Effects of environmental toxicants on the efferent ducts, epididymis and fertility. J Reprod Fertil Suppl 53:247-259. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/10645284
Radovsky A, Mitsumori K, Chapin RE. 1999. Male reproductive tract. In: Pathology of the Mouse: Reference and Atlas (Maronpot RR, Boorman GA, Gaul BW, eds). Cache River Press, Vienna, IL, 381-407. Abstract: http://www.cacheriverpress.com/books/pathmouse.htm
Web page last updated on: August 19, 2014