Epididymis - Sperm Granuloma



comment:
Sperm granulomas occur when sperm is released into the interstitium through a rupture in the epithelial lining or when inflammatory cells gain access to the sperm within the ductular lumen. If there is rupture into the interstitium, the epididymal lining may repair itself and maintain sperm continuity through the epididymal duct. Sperm granulomas are most commonly seen in the cauda epididymis but can occur throughout the epididymis, as well as the efferent ducts. If they occur in the efferent ducts and obstruct the outflow of sperm and fluid from the testis, they will result in secondary tubular dilation and/or atrophy in the associated testis due to the accumulated backpressure upstream. The lesion is characterized by a central accumulation of sperm surrounded by a granulomatous foreign body inflammatory response, which generally contains numerous multinucleated giant cells (arrows, Figure 1

recommendation:
Sperm granulomas should be diagnosed and graded and should be discussed in the pathology narrative if the incidence and/or severity appears to be related to chemical administration. Bilateral involvement should be recorded when present, and a modifier can be used to record location within the epididymis if appropriate. Associated lesions in the epididymides should not be diagnosed separately unless warranted by severity. Associated lesions in the testes may be diagnosed separately and their association to the sperm granuloma noted in the narrative.related links:
Epididymis - Inflammationreferences:
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Creasy D, Bube A, de Rijk E, Kandori H, Kuwahara M, Masson R, Nolte T, Reams R, Regan K, Rehm S, Rogerson P, Whitney K. 2012. Proliferative and nonproliferative lesions of the rat and mouse male reproductive system. Toxicol Pathol 40:40S-121S. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22949412
Kempinas WD, Suarez JD, Roberts NL, Strader L, Ferrell J, Goldman JM, Klinefelter GR. 1998. Rat epididymal sperm quantity, quality, and transit time after guanethidine-induced sympathectomy. Biol Reprod 59:890-896. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/9746740
Klinefelter GR. 2002. Actions of toxicants on the structure and function of the epididymis. In: The Epididymis: From Molecules to Clinical (Robaire B, Hinton BT, eds). New York, Kluwer/Plenum, 353-370. Abstract: http://www.springer.com/medicine/urology/book/978-0-306-46684-7
La DK, Johnson CA, Creasy DM, Hess RA, Baxter E, Pereira M, Snook SS. 2011. Efferent duct toxicity with secondary testicular changes in rats following administration of a novel leukotriene A4 hydrolase inhibitor. Toxicol Pathol 40:705-714. Abstract: http://tpx.sagepub.com/content/40/5/705.short
McGinn JS, Sim I, Bennet NK, McDonald SW. 2000. Observations on multiple sperm granulomas in the rat epididymis following vasectomy. Clin Anat 13:185-194. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/10797625
Sawamoto O, Yamate J, Kuwamura M, Kotani T, Kurisu K. 2003. Development of sperm granulomas in the epididymides of L-cysteine-treated rats. Toxicol Pathol 31:281-289. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/12746115
Tani Y, Sills RC, Foster MD, Chan PC, Peddada SD, Nyska A. 2005. Epididymal sperm granuloma induced by chronic administration of 2-methylimidazole in B6C3F1 mice. Toxicol Pathol 33:313-319. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/15814360
Web page last updated on: August 19, 2014