Reproductive System, Male

Epididymis - Sperm Granuloma

    Narrative
    Epididymis - Sperm Granuloma. Giant cells are present in the sperm granuloma (arrows) in a male B6C3F1 mouse from a chronic study.
    Epididymis - Sperm Granuloma. Higher magnification of Figure 1 showing the granulomatous inflammation and presence of giant cells (arrow) in a male B6C3F1 mouse from a chronic study.
    Epididymis - Sperm Granuloma. A discrete sperm granuloma is present (asterisk) in a male F344/N rat from a subchronic study.
    Epididymis - Sperm Granuloma. Higher magnification of Figure 3 showing the granulomatous reaction in the lumen of the affected duct in a male F344/N rat from a subchronic study.

    Authors:

    Dianne M. Creasy, PhD, Dip RCPath, FRCPath
    Dianne Creasy Consulting LLC
    Pipersville, PA

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Dipak K. Giri, DVM, PhD, DACVP
    Toxicologic Pathologist
    Integrated Laboratory Systems, Inc.
    Research Triangle Park, NC

    Reviewers:

    Mark F. Cesta, DVM, PhD, DACVP
    Staff Scientist, NTP Pathologist
    Cellular and Molecular Pathology Branch
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC

    David E. Malarkey DVM, PhD, DACVP, FIATP
    Head, National Toxicology Program Pathology Group
    Cellular and Molecular Pathology Branch
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC