Epididymis - Sperm Stasis

Epididymis - Sperm Stasis. Ducts filled with sperm in a male B6C3F1 mouse from a chronic study.
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Epididymis - Sperm Stasis. Higher magnification of Figure 1 showing ducts filled with sperm in a male B6C3F1 mouse from a chronic study.
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Epididymis - Sperm Stasis. Sperm stasis is present on the left and ducts without sperm on the right in a male B6C3F1 mouse from a subchronic study.
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comment:
Sperm stasis is most commonly seen in the cauda epididymis following cessation of sperm production by the testis. Sperm become sequestered in the caudal ducts and are intensely eosinophilic ( Figure 1



recommendation:
Sperm stasis should be recorded and graded and should be discussed in the pathology narrative if the incidence and/or severity appears to be related to chemical administration. Bilateral should be indicated when both epididymides are involved, with severity grade based on the more severely affected epididymis. Correlation with any spermatogenic disturbances should be noted in the pathology narrative to aid interpretation.references:
Creasy D, Bube A, de Rijk E, Kandori H, Kuwahara M, Masson R, Nolte T, Reams R, Regan K, Rehm S, Rogerson P, Whitney K. 2012. Proliferative and nonproliferative lesions of the rat and mouse male reproductive system. Toxicol Pathol 40:40S-121S. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22949412
Web page last updated on: August 20, 2014