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    • Preputial Gland, Duct - Dilation

    Image of duct dilation in the preputial gland from a male B6C3F1 mouse in a subchronic study
    Preputial Gland, Duct - Dilation. Ductular dilation in a male B6C3F1 mouse from a subchronic study.
    Figure 1 of 4
    Image of duct dilation in the preputial gland from a male B6C3F1 mouse in a subchronic study
    Preputial Gland, Duct - Dilation. Ductular dilation in a male B6C3F1 mouse from a subchronic study.
    Figure 2 of 4
    Image of duct dilation in the preputial gland from a male F344/N rat in a chronic study
    Preputial Gland, Duct - Dilation. Ductular dilation in a male F344/N rat from a chronic study.
    Figure 3 of 4
    Image of duct dilation in the preputial gland from a male F344/N rat in a chronic study
    Preputial Gland, Duct - Dilation. Ductular dilation in a male F344/N rat from a chronic study.
    Figure 4 of 4
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    comment:

    Figure 1image opens in a pop-up window and Figure 2image opens in a pop-up window show several cystic structures; most are lined by flattened epithelium and are dilated ducts. Ductular dilation may be characterized by accumulation of brightly eosinophilic material consistent with keratin and keratin debris ( Figure 3image opens in a pop-up window and Figure 4image opens in a pop-up window ). The lining epithelium of dilated ducts is often atrophic. Ductular dilatation increases with age.

    recommendation:

    Cyst and ductular dilatation should be recorded and graded. If both glands are involved, the diagnosis should be qualified as bilateral and the severity grade based on the more severely affected gland. Potential treatment-related effects should be documented in the pathology narrative.

    references:

    Haines DC, Chattopadhyay S, Ward JM. 2001. Pathology of aging B6;129 mice. Toxicol Pathol 29:653-661.
    Abstract: http://www.ncbi.nlm.nih.gov/pubmed/11794381

    Rudmann D, Cardiff R, Chouinard L, Goodman D, Kuttler K, Marxfeld H, Molinolo A, Treumann S, Yoshizawa K. 2012. Proliferative and nonproliferative lesions of the rat and mouse mammary, Zymbal's, preputial, and clitoral glands. Toxicol Pathol 40:7S-39S.
    Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22949413

    Seely JC, Boorman GA. 1999. Mammary gland and specialized sebaceous glands. In: Pathology of the Mouse: Reference and Atlas (Maronpot RR, Boorman GA, Gaul BW, eds). Cache River Press, Vienna, IL, 613-635.
    Abstract: http://www.cacheriverpress.com/books/pathmouse.htm

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    Web page last updated on: September 12, 2014