Preputial Gland - Metaplasia, Osseous
comment:Osseous metaplasia characterized by formation of osteoid (asterisk, Figure 2 ), and mineralized osteoid that replaces the glandular parenchymal is an uncommon observation and likely an incidental finding.
recommendation:Osseous metaplasia should be recorded and graded. If both glands are affected, the diagnosis should be qualified as bilateral and the severity based on the more severely affected gland.
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Gordon LR, Majka JA, Boorman GA. 1996. Spontaneous nonneoplastic and neoplastic lesions and experimentally induced neoplasms of the testes and accessory sex glands. In: Pathobiology of the Aging Mouse, Vol 1 (Mohr U, Dungworth DL, Capen CC, Carlton WW, Sundberg JP, Ward JM, eds). ILSI Press, Washington, DC, 421-441. Abstract: http://catalog.hathitrust.org/Record/008994685
Rudmann D, Cardiff R, Chouinard L, Goodman D, Kuttler K, Marxfeld H, Molinolo A, Treumann S, Yoshizawa K. 2012. Proliferative and nonproliferative lesions of the rat and mouse mammary, Zymbal's, preputial, and clitoral glands. Toxicol Pathol 40:7S-39S. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22949413
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