Preputial Gland - Metaplasia, Osseous

Image of metaplasia, osseous in the preputial gland from a male F344/N rat in a chronic study
Preputial Gland - Metaplasia, Osseous. Asterisk indicates osteoid formation; arrows indicate connective tissue stroma in a male F344/N rat from a chronic study. Deep basophilic material is mineralized osteoid.
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Image of metaplasia, osseous in the preputial gland from a male F344/N rat in a chronic study
Preputial Gland - Metaplasia, Osseous. Asterisk indicates osteoid formation with deep basophilic staining of mineralized osteoid in a male F344/N rat from a chronic study.
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comment:

Osseous metaplasia characterized by formation of osteoid (asterisk, Figure 2image opens in a pop-up window ), and mineralized osteoid that replaces the glandular parenchymal is an uncommon observation and likely an incidental finding.

recommendation:

Osseous metaplasia should be recorded and graded. If both glands are affected, the diagnosis should be qualified as bilateral and the severity based on the more severely affected gland.

references:

Boorman GA, Elwell MR, Mitsumori K. 1990. Male accessory sex glands, penis, and scrotum. In: Pathology of the Fischer Rat: Reference and Atlas (Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, 419-428.
Abstract: http://www.ncbi.nlm.nih.gov/nlmcatalog/9002563

Gordon LR, Majka JA, Boorman GA. 1996. Spontaneous nonneoplastic and neoplastic lesions and experimentally induced neoplasms of the testes and accessory sex glands. In: Pathobiology of the Aging Mouse, Vol 1 (Mohr U, Dungworth DL, Capen CC, Carlton WW, Sundberg JP, Ward JM, eds). ILSI Press, Washington, DC, 421-441.
Abstract: http://catalog.hathitrust.org/Record/008994685

Rudmann D, Cardiff R, Chouinard L, Goodman D, Kuttler K, Marxfeld H, Molinolo A, Treumann S, Yoshizawa K. 2012. Proliferative and nonproliferative lesions of the rat and mouse mammary, Zymbal's, preputial, and clitoral glands. Toxicol Pathol 40:7S-39S.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22949413