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Preputial Gland - Mineralization

Image of mineralization in the preputial gland from a male F344/N rat in a subchronic study
Preputial Gland - Mineralization. Arrow indicates mineral deposits in a male F344/N rat from a subchronic study.
Figure 1 of 2
Image of mineralization in the preputial gland from a male F344/N rat in a subchronic study
Preputial Gland - Mineralization. Arrows indicate mineral deposits in a male F344/N rat from a subchronic study.
Figure 2 of 2
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comment:

Mineralization consists of deposition of irregular amorphous basophilic material (arrows, Figure 1image opens in a pop-up window and Figure 2image opens in a pop-up window ). Two types of mineralization may occur: metastatic (calcification of normal tissue associated with high blood levels of calcium) or dystrophic (mineral deposits in abnormal or degenerating tissue not associated with increased blood levels of calcium). When systemic, metastatic mineralization can be present in multiple organs. Mineralization can be focal or multifocal. Mineralization in the preputial gland is unusual and is likely an incidental finding unrelated to chemical treatment. However, it may be associated with inflammation ( Figure 2image opens in a pop-up window ).

recommendation:

Mineralization should be recorded and given a severity grade. If both glands are affected, the diagnosis should be qualified as bilateral and the severity based on the more severely affected gland. If it occurs in multiple tissues as a systemic response, it is not necessary to separately diagnose mineralization in the preputial gland. However, its presence in the preputial gland may be mentioned in the pathology narrative.

references:

Boorman GA, Elwell MR, Mitsumori K. 1990. Male accessory sex glands, penis, and scrotum. In: Pathology of the Fischer Rat: Reference and Atlas (Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, 419-428.
Abstract: http://www.ncbi.nlm.nih.gov/nlmcatalog/9002563

Gordon LR, Majka JA, Boorman GA. 1996. Spontaneous nonneoplastic and neoplastic lesions and experimentally induced neoplasms of the testes and accessory sex glands. In: Pathobiology of the Aging Mouse, Vol 1 (Mohr U, Dungworth DL, Capen CC, Carlton WW, Sundberg JP, Ward JM, eds). ILSI Press, Washington, DC, 421-441.
Abstract: http://catalog.hathitrust.org/Record/008994685

Haines DC, Eustis SL. 1990. Specialized sebaceous glands. In: Pathology of the Fischer Rat: Reference and Atlas (Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, 279-293.
Abstract: http://www.ncbi.nlm.nih.gov/nlmcatalog/9002563

Rudmann D, Cardiff R, Chouinard L, Goodman D, Kuttler K, Marxfeld H, Molinolo A, Treumann S, Yoshizawa K. 2012. Proliferative and nonproliferative lesions of the rat and mouse mammary, Zymbal's, preputial, and clitoral glands. Toxicol Pathol 40:7S-39S.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22949413

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.