Prostate, Acinus - Dilation
comment:Ectasia or dilation of the prostate is characterized by acini that are sometimes distended with secretory material and lined by attenuated epithelial cells ( Figure 1 , Figure 2 , Figure 3 , and Figure 4 ). There may be marked acinar enlargement, particularly with significant compression of surrounding unaffected acini and parenchyma, with the dilation appearing cystic ( Figure 3 and Figure 4 ). Affected acinar secretory material can exhibit either a near normal staining reaction ( Figure 1 and Figure 2 ) or can be poorly stained as in the quiescent gland shown in Figure 3 and Figure 4 . Affected acini can be observed in any lobe and can involve either a part or the entire lobe. This is likely an age-related lesion and may be associated with interstitial inflammation.
recommendation:Prostatic dilatation should be recorded and given a severity grade during histopathologic evaluation of prostate from toxicity studies. The affected lobe(s) should be identified if possible and indicated in the tissue identification (e.g., prostate, dorsolateral lobe, acinus - dilation, moderate). If paired lobes are both affected, the diagnosis should be qualified as bilateral, with severity based on the more severely affected gland.
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