Prostate - Mineralization

comment:
Mineralization is characterized by focal to diffuse accumulation of basophilic, anisotropic, irregular granular material that may involve the glandular acini ( Figure 1

recommendation:
Mineralization should be diagnosed during histopathologic evaluation of prostate and given a severity grade. The affected lobe(s) should be identified if possible and indicated in the tissue identification. If paired lobes are affected, the diagnosis should be indicated as bilateral and the degree of severity based on more severely affected lobe.references:
Boorman GA, Elwell MR, Mitsumori K. 1990. Male accessory sex glands, penis, and scrotum. In: Pathology of the Fischer Rat: Reference and Atlas (Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, 419-428. Abstract: http://www.ncbi.nlm.nih.gov/nlmcatalog/9002563
Bosland MC. 1992. Lesions in the male accessory glands and penis. In: Pathobiology of the Aging Rat, Vol 1 (Mohr U, Dungworth DL, Capen CC, eds). ILSI Press, Washington, DC, 443-467. Abstract: http://catalog.hathitrust.org/Record/008994685
Greaves P. 2007. Male genital tract. In: Histopathology of Preclinical Toxicity Studies: Interpretation and Relevance in Drug Safety Evaluation. 3rd ed. Academic Press, San Diego, 661-716. Abstract: http://www.sciencedirect.com/science/book/9780444527714
Mitsumori K. 1990. Blood and lymphatic vessels. In: Pathology of the Fischer Rat: Reference and Atlas (Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, 473-484. Abstract: http://www.ncbi.nlm.nih.gov/nlmcatalog/9002563
Suwa T, Nyska A, Peckham JC, Hailey JR, Mahler JF, Haseman JK, Maronpot RR. 2001. A retrospective analysis of background lesions and tissue accountability for male accessory sex organs in Fischer-344 rats. Toxicol Pathol 29(4):467-478. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/11560252
Suwa T, Nyska A, Haseman JK, Mahler JF, Maronpot RR. 2002. Spontaneous lesions in control B6C3F1 mice and recommended sectioning of male accessory sex organs. Toxicol Pathol 30(2):228-234. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/11950166
Web page last updated on: August 20, 2014