Seminal Vesicle - Atrophy



comment:
Seminal vesicle atrophy is characterized by a reduction in the size and number of glandular components and lining epithelial cells of the seminal vesicle. This is associated with secretory depletion and an increased prominence of the contracted fibromuscular stroma. Atrophy may be accompanied by the formation of small papillary folds in the glands ( Figure 1



recommendation:
Seminal vesicle atrophy should be diagnosed and graded. When present In both seminal vesicles, the diagnosis should be clarified as bilateral and severity based on the more severely affected seminal vesicle. Comments in the pathology narrative should address whether seminal vesicle atrophy is exacerbated by treatment and should identify related changes in other male reproductive tissues.references:
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Bosland MC. 1992. Lesions in the male accessory glands and penis. In: Pathobiology of the Aging Rat, Vol 1 (Mohr U, Dungworth DL, Capen CC, eds). ILSI Press, Washington, DC, 443-467. Abstract: http://catalog.hathitrust.org/Record/008994685
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Gayton F, Bellido C, Aguilar R, Lucena MC. 1986. Morphometric analysis of the rat ventral prostate and seminal vesicles during prepubertal development: Effects of neonatal treatment with estrogen. Biol Reprod 35:219-225. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/3741952
Gordon LR, Majka JA, Boorman GA. 1996. Spontaneous nonneoplastic and neoplastic lesions and experimentally induced neoplasms of the testes and accessory sex glands. In: Pathobiology of the Aging Mouse, Vol 1 (Mohr U, Dungworth DL, Capen CC, Carlton WW, Sundberg JP, Ward JM, eds). ILSI Press, Washington, DC, 421-441. Abstract: http://catalog.hathitrust.org/Record/008994685
Greaves P. 2007. Male genital tract. In: Histopathology of Preclinical Toxicity Studies: Interpretation and Relevance in Drug Safety Evaluation. 3rd ed. Academic Press, San Diego, 661-716. Abstract: http://www.sciencedirect.com/science/book/9780444527714
Suwa T, Nyska A, Peckham JC, Hailey JR, Mahler JF, Haseman JK, Maronpot RR. 2001. A retrospective analysis of background lesions and tissue accountability for male accessory sex organs in Fischer-344 rats. Toxicol Pathol 29(4):467-478. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/11560252
Suwa T, Nyska A, Haseman JK, Mahler JF, Maronpot RR. 2002. Spontaneous lesions in control B6C3F1 mice and recommended sectioning of male accessory sex organs. Toxicol Pathol 30(2):228-234. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/11950166
Web page last updated on: August 22, 2014