Testis - Amyloid

Testis - Amyloid in a male B6C3F1 mouse from a chronic study. There are perivascular accumulations of hemogenous, eosinophilic material in the interstitium (arrows).
Figure 1 of 4

Testis - Amyloid in a male B6C3F1 mouse from a chronic study. Higher magnification of Figure 1 with perivascular accumulation of amyloid (arrow).
Figure 2 of 4

Testis - Amyloid in a male Swiss CD-1 mouse from a chronic study. Widespread accumulation of amyloid with secondary tubular degeneration and necrosis.
Figure 3 of 4
comment:
Testicular amyloid consists of extracellular accumulation of homogeneous, eosinophilic and amorphous material in the interstitium (arrows, Figure 1








recommendation:
Whenever present, amyloid should be diagnosed and graded and should be discussed in the pathology narrative if the incidence and/or severity appears to be related to chemical administration. Bilaterality should be indicated in the diagnosis if present. Associated lesions such as germ cell degeneration or germinal epithelium atrophy should not be diagnosed separately unless warranted by their severity, but should be described in the narrative.references:
Creasy D, Bube A, de Rijk E, Kandori H, Kuwahara M, Masson R, Nolte T, Reams R, Regan K, Rehm S, Rogerson P, Whitney K. (2012). Proliferative and nonproliferative lesions of the rat and mouse male reproductive system. Toxicol Pathol 40:40S-121S. Abstract: https://doi.org/10.1177/0192623312454337
Gordon LR, Majka JA, Boorman GA. 1996. Spontaneous nonneoplastic and neoplastic lesions and experimentally induced neoplasms of the testes and accessory sex glands. In: Pathobiology of the Aging Mouse, Vol 1 (Mohr U, Dungworth DL, Capen CC, Carlton WW, Sundberg JP, Ward JM, eds). ILSI Press, Washington, DC, 421-441. Abstract: http://catalog.hathitrust.org/Record/008994685
Web page last updated on: July 25, 2014