U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Skip to Main Navigation
Skip to Page Content
Skip to Atlas Navigation

Testis - Atypical Residual Bodies

Image of atypical residual bodies in the testis from a male B6C3F1 mouse in a subchronic study
Testis - Atypical residual bodies in a B6C3F1 mouse from a subchronic study. Seminiferous tubules show atypical residual bodies.
Figure 1 of 4
Image of atypical residual bodies in the testis from a male B6C3F1 mouse in a subchronic study
Testis - Atypical residual bodies in a B6C3F1 mouse from a subchronic study. Atypical residual bodies in a seminiferous tubule.
Figure 2 of 4
Image of atypical residual bodies in the testis from a male B6C3F1 mouse in a subchronic study
Testis - Atypical residual bodies in a B6C3F1 mouse in a subchronic study. Higher magnification of the atypical residual bodies shown in Figure 1.
Figure 3 of 4
Image of atypical residual bodies in the testis from a male B6C3F1 mouse in a subchronic study
Testis - Atypical residual bodies in a B6C3F1 mouse in a subchronic study. A seminiferous tubule shows atypical residual bodies.
Figure 4 of 4
next arrow
View all images

comment:

Residual bodies are dense basophilic, globular bodies comprising redundant organelles and excess cytoplasm shed from the elongating spermatid in its final steps of maturation. They are generally seen at the luminal surface of stage VII and VIII tubules intermixed with the heads of the mature spermatids. Once spermiation has occurred, the residual bodies rapidly descend to the basal region of the stage IX and X tubule, where they are phagocytized and disappear. Abnormally large residual bodies can sometimes be seen as an incidental background finding in mice or as a chemically induced degenerative change in mice and rats. Atypical residual bodies are generally larger than normal and have the appearance of apoptotic bodies ( Figure 1image opens in a pop-up window , Figure 2image opens in a pop-up window , Figure 3image opens in a pop-up window , and Figure 4image opens in a pop-up window ). They are generally at the luminal surface or appear suspended in the lumen of tubules and can sometimes be seen in tubular stages where normal residual bodies are never present ( Figure 2image opens in a pop-up window ). Their significance is unclear, but they probably represent a disruption of the spermiation process. They have been described in rats in response to administration of tri-o-cresyl phosphate and the water disinfectant chemical dibromoacetic acid.

recommendation:

Atypical residual bodies should be diagnosed and graded and should be discussed in the pathology narrative if the incidence and/or severity appears to be related to chemical administration. Bilateral involvement should be diagnosed when present.

references:

Creasy DM. 2012. Reproduction of the rat, primate, dog and pig. In: Background Lesions in Laboratory Animals: A Colour Atlas (McKinnes E, ed). Saunders Elselvier, Edinburgh. 101-122.
Abstract: http://www.sciencedirect.com/science/book/9780702035197

Creasy D, Bube A, de Rijk E, Kandori H, Kuwahara M, Masson R, Nolte T, Reams R, Regan K, Rehm S, Rogerson P, Whitney K. (2012). Proliferative and nonproliferative lesions of the rat and mouse male reproductive system. Toxicol Pathol 40:40S-121S.
Abstract: https://doi.org/10.1177/0192623312454337

Linder RE, Klinefelter GR, Strader LF, Suarez JD, Roberts NL, Dyer CJ. 1994. Spermatotoxicity of dibromoacetic acid in rats after 14 daily exposures. Reprod Toxicol 8:251-259.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/8075514

Linder RE, Klinefelter GR, Strader LF, Veermachaneni DNR, Roberts NL, Suarez JD. 1997. Histopathologic changes in testes of rats exposed to dibromoacetic acid. Reprod Toxicol 11:47-56.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/9138633

Somkuti SG, Lapadula DM, Chapin RE, Abou-Donia MB. 1991. Light and electron microscopic evidence of tri-o-cresyl phosphate (TOCP)-mediated testicular toxicity in Fischer 344 rats. Toxicol Appl Pharmacol 107:35-46.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/1987658

Back to top

Web page last updated on: July 25, 2014