Testis, Germ Cell - Exfoliation

comment:
Germ cells may undergo degeneration and/or apoptosis within the seminiferous epithelium, or they may lose contact with the surrounding Sertoli cell cytoplasmic processes and be shed into the tubular lumen ( Figure 1

recommendation:
The term "germ cell exfoliation" should be reserved for those situations where there is extensive shedding of germ cells into the lumen as a predominant finding. In those situations, germ cell exfoliation should be diagnosed and graded and should be discussed in the pathology narrative if the incidence and/or severity appears to be related to chemical administration. Bilateral involvement should be diagnosed when present. If there is significant concurrent germ cell degeneration, that should also be diagnosed and given a severity grade.references:
Correa LM, Nakai M, Strandgaard CS, Hess RA, Miller MG. 2002. Microtubules of the mouse testis exhibit differential sensitivity to the microtubule disruptors carbendazim and colchicine. Toxicol Sci 69:175-182. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/12215672
Creasy DM. 2001. Pathogenesis of male reproductive toxicity. Toxicol Pathol 29:64-76. Full Text: http://tpx.sagepub.com/content/29/1/64.full.pdf
Creasy D, Bube A, de Rijk E, Kandori H, Kuwahara M, Masson R, Nolte T, Reams R, Regan K, Rehm S, Rogerson P, Whitney K. (2012). Proliferative and nonproliferative lesions of the rat and mouse male reproductive system. Toxicol Pathol 40:40S-121S. Abstract: https://doi.org/10.1177/0192623312454337
Nakai M, Hess RA. 1994. Morphological changes in the rat Sertoli cell induced by the microtubule poison carbendazim. Tissue Cell 26:917-127. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/7886678
Russell LD, Malone JP, MacCurdy DS. 1981. Effect of the microtubule disrupting agents, colchicine and vinblastine, on seminiferous tubule structure in the rat. Tissue Cell 13:349-367. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/7314074
Web page last updated on: January 18, 2019