Testis, Interstitial Cell - Vacuolation

Testis, Interstitial cell - Vacuolation in a male FVB/N transgenic mouse from a chronic study. The interstitial cells contain variably sized vacuoles.
Figure 1 of 3

Testis, Interstitial cell - Vacuolation in a male FVB/N transgenic mouse from a chronic study. This higher magnification of Figure 1 shows the vacuolation of interstitial cells.
Figure 2 of 3
comment:
Cytoplasmic vacuolation of interstitial cells can be seen as a chemically induced change and most likely represents a disturbance in steroidogenesis. It generally consists of enlarged, pale-staining interstitial cells with foamy vacuolation of the cytoplasm ( Figure 1





recommendation:
Interstitial cell vacuolation should be diagnosed and graded and should be discussed in the pathology narrative if the incidence and/or severity appears to be related to chemical administration. Diagnosis should indicate bilaterality when present.references:
Creasy D, Bube A, de Rijk E, Kandori H, Kuwahara M, Masson R, Nolte T, Reams R, Regan K, Rehm S, Rogerson P, Whitney K. (2012). Proliferative and nonproliferative lesions of the rat and mouse male reproductive system. Toxicol Pathol 40:40S-121S. Abstract: https://doi.org/10.1177/0192623312454337
Web page last updated on: July 25, 2014