Testis - Mineralization

Image of mineralization in the testis from a male B6C3F1 mouse in a chronic study
Testis - Mineralization in a male B6C3F1 mouse from a chronic study. Mineralization involving the testicular capsule.
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Image of mineralization in the testis from a male B6C3F1 mouse in a chronic study
Testis - Mineralization in a male B6C3F1 mouse from a subchronic study. Mineralization involving seminiferous tubules.
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Image of mineralization in the testis from a male F344/N rat in a chronic study
Testis - Mineralization in a male F344/N rat from a chronic study. Mineralization involving blood vessels.
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Image of mineralization in the testis from a male B6C3F1 mouse in a chronic study
Testis - Mineralization in a male B6C3F1 mouse from a chronic study. Mineralized seminiferous tubules.
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comment:

Dystrophic mineralization is a sequel of injury and may involve the capsule ( Figure 1image opens in a pop-up window ), blood vessels ( Figure 3image opens in a pop-up window ), or seminiferous tubules ( Figure 2image opens in a pop-up window and Figure 4image opens in a pop-up window ). It is characterized by accumulation of basophilic, fine to coarsely granular to amorphous, laminated material, with or without distortion of the tissue architecture. It is often a sequel to sperm stasis within the seminiferous tubules. Mineralization is an age-related finding and can be seen unilaterally or bilaterally.

recommendation:

Mineralization should be diagnosed, graded, and classified with respect to location through appropriate use of site modifiers (e.g., blood vessel, capsule, seminiferous tubule). If present in both testes, it should be diagnosed as bilateral. Associated lesions, such as degeneration, necrosis, or inflammation should be diagnosed separately if warranted by severity.

references:

Creasy D, Bube A, de Rijk E, Kandori H, Kuwahara M, Masson R, Nolte T, Reams R, Regan K, Rehm S, Rogerson P, Whitney K. (2012). Proliferative and nonproliferative lesions of the rat and mouse male reproductive system. Toxicol Pathol 40:40S-121S.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22949412