Testis, Seminiferous Tubule -Vacuolation

comment:
Seminiferous tubule vacuolation can be microvacuolar or macrovacuolar in appearance. Microvacuolation generally occurs in the basal Sertoli cell cytoplasm ( Figure 1


recommendation:
Seminiferous tubule vacuolation should be diagnosed and graded and should be discussed in the pathology narrative if the incidence and/or severity appears to be related to chemical administration. If present in both testes, the vacuolation should be recorded as bilateral and the severity grade based on the more severely affected testis.references:
Creasy DM. 2001. Pathogenesis of male reproductive toxicity. Toxicol Pathol 29:64-76. Full Text: http://tpx.sagepub.com/content/29/1/64.full.pdf
Creasy D, Bube A, de Rijk E, Kandori H, Kuwahara M, Masson R, Nolte T, Reams R, Regan K, Rehm S, Rogerson P, Whitney K. (2012). Proliferative and nonproliferative lesions of the rat and mouse male reproductive system. Toxicol Pathol 40:40S-121S. Abstract: https://doi.org/10.1177/0192623312454337
Hild SA, Reel JR, Larener JM, Blye RP. 2001. Disruption of spermatogenesis and Sertoli cell structure and function by the indenopyridine CDB-4022 in rats. Biol Reprod 65:1771-1779. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/11717140
Kerr JB, Savage GN, Millar M, Sharpe RM. 1993. Response of the seminiferous epithelium of the rat testis to withdrawal of androgen: Evidence for direct effect upon intercellular spaces associated with Sertoli cell junctional complexes. Cell Tissue Res 274:153-161. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/8242704
Web page last updated on: August 19, 2014