Musculoskeletal System

Bone - Decreased Bone

    Narrative
    Bone - Decreased bone in a female B6C3F1/N mouse from a chronic study. There is focal thinning of cortical bone and loss of metaphyseal trabeculae (arrowheads).
    Bone - Decreased bone in a female B6C3F1/N mouse. Although the width of the bone is increased focally (arrowheads), the density is decreased due to thinning of cortical bone and redundant cortical spaces.
    Bone - Decreased bone in a female F344/N rat from a subchronic study. There is loss of medullary trabeculae within the metaphyseal region in this section of long bone.
    Bone - Decreased bone in a female F344/N rat from a subchronic study. There is loss of medullary trabeculae within the metaphyseal region.

    Authors

    Mark J. Hoenerhoff, DVM, PhD, DACVP
    Associate Professor
    In Vivo Animal Core,Unit for Laboratory Animal Medicine
    University of Michigan
    Ann Arbor, MI

    Amy Brix, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Reviewers

    Philip H. Long, DVM, PhD, DACVP
    Presiden and Senior Pathologist
    Vet Path Services, Inc.
    Mason, OH

    Joel R. Leininger, DVM, PhD, DACVP
    JRL Consulting, LLC
    Chapel Hill, NC