Musculoskeletal System

Bone - Fibrous Osteodystrophy

    Narrative
    Bone - Fibrous osteodystrophy in a male F344/N rat from a chronic study. There is replacement of bone by fibrous connective tissue.
    Bone - Fibrous osteodystrophy in a male F344/N rat from a chronic study (same animal as in Figure 1). There is replacement of cortical bone by fibrous connective tissue.
    Bone - Fibrous osteodystrophy in a male F344/N rat from a chronic study (higher magnification of Figure 2). The lesion is characterized by osteoclastic resorption of bone with replacement by fibrous connective tissue.

    Authors

    Mark J. Hoenerhoff, DVM, PhD, DACVP
    Associate Professor
    In Vivo Animal Core,Unit for Laboratory Animal Medicine
    University of Michigan
    Ann Arbor, MI

    Amy Brix, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Reviewers

    Philip H. Long, DVM, PhD, DACVP
    Presiden and Senior Pathologist
    Vet Path Services, Inc.
    Mason, OH

    Joel R. Leininger, DVM, PhD, DACVP
    JRL Consulting, LLC
    Chapel Hill, NC